CompARing Long terM Outcomes in Chronic Stroke Survivors Across Investigational Assessments Following a Prescribed Upper Extremity Exercise Program

CompARing Long terM Outcomes in Chronic Stroke Survivors Across Investigational Assessments Following a Prescribed Upper Extremity Exercise Program (ARM-PROGRAM)

The purpose of the study is to compare assessments of arm function following a standard exercise program in chronic stroke patients.

Inclusion Criteria:

• Single qualifying stroke event as confirmed by CT or MRI
• At least 1 month post stroke
• Score of at least 2-/5 on Manual Muscle Test for wrist flexors or extensors, indicating adequate movement to complete robotic device use
• Able to follow written instructions

Exclusion Criteria:

• Prior arm injury impacting available passive or active range of motion or significant arm pain with movement
• Underlying brain pathologies such as metastatic or primary brain malignancies, comorbid multiple sclerosis, etc.
• Prior significant drug or alcohol abuse
• Diagnosed with dementia
• Pre-stroke baseline modified Rankin Scale (mRS) >3
• History of seizure/epilepsy
• History of clinically significant ischemic or hemorrhagic stroke prior to index stroke resulting in prior arm injury or weakness.
• Pregnancy
• Contraindication to MRI or Transcranial Magnetic Stimulation (TMS).
• Medical instability assessed by the treating stroke physician to participate to the study.