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The postoperative recurrence of Crohn's diseases (CD) remains high. Stapled anti-mesenteric functional end-to-end anastomosis was safe for CD patients. Its impact on the postoperative recurrence of CD was unknown. Whether it is superior than the conventional anastomosis (stapled antimesenteric isoperistaltic side-to-side anastomosis) needs explored. The trial aims to compare the different impacts of the two antimesenteric anastomosis configurations on the anastomotic recurrence following bowel resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kono-S group | Experimental | patients in this arm will receive stapled Kono-S anastomosis after bowel resection |
|
| Side-to-side group | Other | patients in this arm will receive stapled antimesenteric isoperistaltic side-to-side anastomosis after bowel resection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Kono-S group | Procedure | patients in this arm will receive stapled Kono-S anastomosis after bowel resection |
|
| Measure | Description | Time Frame |
|---|---|---|
| the endoscopic recurrence rate at 1 year after surgery | the endoscopic recurrence rate at 1 year after surgery | at 1 year after surgery(6-18month) |
| Measure | Description | Time Frame |
|---|---|---|
| the clinical recurrence rate at 1 and 5 year after surgery | the clinical recurrence rate at 1 and 5 year after surgery | 1 and 5 year after surgery |
| the surgical recurrence rate at 1 and 5 year after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ming duan, M.D. | Contact | +86-025-80860036 | duanming1206@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Li, Ph.D | Jinling Hospital,Nanjing, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of General Surgery, Jinling hosptal,Medical School of Nanjing University | Recruiting | Nanjing | Jiangsu | 210002 | China |
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| Side-to-side group | Procedure | patients in this arm will receive stapled antimesenteric isoperistaltic side-to-side anastomosis after bowel resection |
|
the surgical recurrence rate at 1 and 5 year after surgery
| 1 and 5 year after surgery |
| the endoscopic recurrence rate at 1 year after surgery | the endoscopic recurrence rate at 1 year after surgery | 1 and 5 year after surgery |
| quality of life for CD patients inflammatory bowel disease questionnaire(IBDQ) | IBDQ , higher means better,IBDQ,7-224; | 1 and 5 year after surgery |
| quality of life for CD patients Short Form 12 | Short Form 12 , higher means better,Short Form-12, 0-12; | 1 and 5 year after surgery |
| D007410 | Intestinal Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |