Alternative Surveillance Program for Patients With High Risk Group of HCC

Alternative Surveillance Program for Prospective Cohort of a Super-high Risk Group of Developing HCC

In a high-risk group, ultrasonography at 6-month intervals and short-protocol magnetic resonance imaging at 1-year intervals were performed. sensitivity, specificity, positive and negative predictive values for very early stage HCC are compared between conventional (biannual US) and alternative surveillance test are compared

Inclusion Criteria:

• chronic hepatitis B or C
• Child-Pugh classification A
• HCC risk score >= -2.04
• have not diagnosed with HCC
• on surveillance program using US and negative on previous US within 6-8 months of enrollment
• sign informed consent

Exclusion Criteria:

• younger than 40 years or older than 70 years old
• history of HCC
• severe GFR or on HD/PD due to renal failure
• contra-indication of MRI
• congestive hepatopathy
• iron deposition
• pregnancy or nursing mother
• non-viral hepatitis or liver cirrhosis