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| Name | Class |
|---|---|
| Severance Hospital | OTHER |
| The Catholic University of Korea | OTHER |
| Korea University Guro Hospital | OTHER |
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In a high-risk group, ultrasonography at 6-month intervals and short-protocol magnetic resonance imaging at 1-year intervals were performed. sensitivity, specificity, positive and negative predictive values for very early stage HCC are compared between conventional (biannual US) and alternative surveillance test are compared
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| US & MRI | Experimental | All participants undergo biannual US (as a part of standard-of-care) and annual non-contrast focused MRI. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-contrast focused MRI | Diagnostic Test | non-contrast liver MRI focusing on HCC surveillance in a short scan time. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of alternative surveillance program (alternating focused MRI + US in 6 month interval) and conventional surveillance (biannual US) for HCC detection | per-patient sensitivity, specificity, positive predictive value, negative predictive value for very early stage HCC, early stage HCC, all stage of HCC/liver cancer. | up to one year |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of annual focused MRI and biannual US for HCC detection | per-patient sensitivity, specificity, positive predictive value, negative predictive value for very early stage HCC, early stage HCC, all stage of HCC/liver cancer. | up to one year |
| diagnostic yield for HCC |
| Measure | Description | Time Frame |
|---|---|---|
| comparison between incidental findings between biannual US and annual focused MRI | comparison of incidental findings detected between biannual US and annual focused MRI. | up to one year |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeong Hee Yoon, MD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 03080 | South Korea |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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HCC incidence in the group and detection rate with either US or focused MRI |
| up to one year |
| scan time of focused MRI | in room time, table time are manually recorded | up to one month |
| comparison between false referral rates of biannual US and annual focused MRI | comparison between false positive report/finding for HCC in each surveillance modality. | up to one year |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |