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Cat allergy is the most common animal allergy, affecting approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals is increasing, and cat allergy is a major risk factor for the development of asthma and rhinitis.
Fel-d1 is the major feline allergen, to which 95% of cat allergic people react. All cats produce Fel-d1 regardless of breed, age, coat type, sex or weight. Fel-d1 is contained primarily in the saliva and sebum of cats.
This allergy manifests itself as allergic rhinitis (AR) (sneezing, cold, coughing, conjunctivitis with watering and itching), severe asthma, and irritation and swelling of the skin when scratched.
A new approach to managing cat allergies is to neutralize the allergens at the source by feeding domestic cats a diet containing anti-Fel-d1 IgY antibodies. The purpose of this pilot study is to determine whether feeding domestic cats a food containing an egg product with anti-Fel d1 IgY (PRO PLAN® LIVECLEAT®) induces a reduction of allergic symptoms in their owners.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cats fed with PRO PLAN® LIVECLEAT® | Other | Patient with domestic cats fed with an egg product containing anti-Fel d1 IgY (PRO PLAN® LIVECLEAT®) |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the global Visual Analogic Scale (VAS) mean from Baseline period (Day 0- Day 15) at end period (Day 98-Day112) | The approach will be considered beneficial if there is a statistically significant decrease in this criterion on the D98-J112 period compared to the baseline. | Baseline (Day 0- Day 15) and observation period (Day 98-Day112) |
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Inclusion Criteria:
Exclusion Criteria:
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a total of 50 Allergic patient to cats is expected.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Batot Géraldine, PhD | Contact | +33 6 08 82 81 47 | geraldine.batot@kyomed.com |
| Name | Affiliation | Role |
|---|---|---|
| Nan Pham-Thi, Dr | Allergologist | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cabinet médical Lion de Raspail | Recruiting | Paris | 75014 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38676659 | Derived | Bousquet J, Gherasim A, de Blay F, Mathieu-Dupas E, Batot G, Laune D, Sousa-Pinto B, Zuberbier T, Pham-Thi N; MASK-cat study group. Proof-of-concept study of anti-Fel d 1 IgY antibodies in cat food using the MASK-air(R) app. Clin Transl Allergy. 2024 May;14(5):e12353. doi: 10.1002/clt2.12353. |
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| ID | Term |
|---|---|
| D065631 | Rhinitis, Allergic |
| ID | Term |
|---|---|
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
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| D010038 |
| Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |