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The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy. The main questions aims to answer are:
• does application of vancomycine prior to ECMO liberation have an impact of bloodstream infections?
Participants will get 1 dose of vancomycine I.V. (15-20 mg per kgKG) prior to liberation of ECMO.
Researchers will compare this interventional group to a group without antibiotic prophylaxis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention: Prophylactic antibiotic treatment | Active Comparator | Application of 15-20 mg per kgKG Vancomycine I.V. prior to ECMO liberation |
|
| Control Arm: No prophylactic antibiotic treatment | No Intervention | Control group - no intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vancomycine | Drug | Application of 15-20 mg per kgKG Vancomycine I.V. prior to ECMO liberation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Growth of pathogens in blood culture | Detection of pathogens / blood stream infection | taken 72 hours after liberation of extracorporeal membrane oxygenation therapy |
| Growth of pathogens in blood culture | Detection of pathogens / blood stream infection | taken directly before removal of extracorporeal membrane oxygenation therapy |
| Measure | Description | Time Frame |
|---|---|---|
| Growth of pathogens on cannula tip | Detection of growth of pathogens on cannulas | on the day of liberation, cannula tip will be send to institute of microbiology directly after liberation from ECMO |
| laboratory parameters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carsten Zeiner, MD | Contact | +49684116 | 21624 | carsten.zeiner@uks.eu |
| Philipp M Lepper, MD | Contact | +49684116 | 15055 | philipp.lepper@uks.eu |
| Name | Affiliation | Role |
|---|---|---|
| Philipp M Lepper, MD | Saarland University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Saarland | Homburg | Saarland | 66421 | Germany |
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| ID | Term |
|---|---|
| D055499 | Catheter-Related Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
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| ID | Term |
|---|---|
| D014640 | Vancomycin |
| ID | Term |
|---|---|
| D006020 | Glycopeptides |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D010455 | Peptides |
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leukocytes, procalcitonin, C-reactive protein
| 6.00 am on the day of liberation of extracorporeal membrane oxygenation therapy |
| laboratory parameters | leukocytes, procalcitonin, C-reactive protein | 24 hours after liberation of extracorporeal membrane oxygenation therapy |
| laboratory parameters | leukocytes, procalcitonin, C-reactive protein | 48 hours after liberation of extracorporeal membrane oxygenation therapy |
| laboratory parameters | leukocytes, procalcitonin, C-reactive protein | 72 hours after liberation of extracorporeal membrane oxygenation therapy |
| D000602 |
| Amino Acids, Peptides, and Proteins |