Multiphasic Prehab Allo-HSCT

A Multiphasic Prehabilitation Exercise Program For Allogeneic Hematopoietic Stem Cell Transplant Recipients

The purpose of this study is to implement a prehabilitation intervention to enhance recovery for people undergoing allogeneic stem cell transplant for hematologic malignancies. All participants in this study will receive a prehabilation intervention in addition to usual care (no change to their chemotherapy protocols or transplant) and several quality of life and fitness scores will be measured throughout the intervention.

Inclusion Criteria:

• Adult patients, 18 years or older, undergoing an allo-HSCT for acute leukemia.
• Approval to engage in exercise as per screening by the CSEP or ACSM certified CEP and/or clinician
• Ability to provide written informed consent and understand study information.

Exclusion Criteria:

• Less than 18 years old
• Diagnosed with acute leukemia but not undergoing work-up for allo-HSCT
• Unable to read/communicate in English (i.e., unable to complete experimental procedures such as patient-reported outcomes).
• Neurological or musculoskeletal comorbidity inhibiting exercise.
• Diagnosed psychotic, addictive, or major cognitive disorders.
• Severe coronary artery disease (Canadian Cardiovascular Society class III or greater).
• Significant congestive heart failure (New York Heart Association class III or greater).
• Severe thrombocytopenia (platelets <10) - ok if transfused platelets prior to exercise.