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Business Reasons
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A long-term follow-up study to assess safety and efficacy in patients previously treated with Mustang Bio chimeric antigen receptor (CAR)-T cell investigational products.
Non-interventional, multi-center, long-term follow-up study of subjects previously treated with a Mustang Bio CAR-T cell investigational product in a Mustang Bio sponsored clinical study. Subjects who enroll will be monitored for a total of up to 15 years from the time of their last investigational product infusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prior MB-102 CAR-T cell investigational product. | Patients previously treated with MB-102 CAR-T cell investigational product. |
| |
| Prior MB-106 CAR-T cell investigational product. | Patients previously treated with MB-106 CAR-T cell investigational product. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prior MB-102 CAR-T cell investigational product. | Biological | No investigational product will be administered. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events (AEs) | Incidence and characterization of adverse events (AEs) related to prior treatment with a Mustang Bio CAR-T cell investigational product received in a Mustang Bio sponsored clinical study. | Up to a total of 15 years |
| Replication competent lentivirus (RCL) | Detection of replication competent lentivirus (RCL). | Up to a total of 15 years |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | Overall Survival. | Up to a total of 15 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients previously treated with a Mustang Bio CAR-T cell investigational product in a Mustang Bio sponsored clinical study.
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| Name | Affiliation | Role |
|---|---|---|
| Bruce Dezube, M.D. | Mustang Bio | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Orange | California | 92868-3201 | United States | ||
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Peripheral blood
| Prior MB-106 CAR-T cell investigational product. | Biological | No investigational product will be administered. |
|
| Massachusetts General Hospital |
| Boston |
| Massachusetts |
| 02114 |
| United States |
| University of Rochester Medical Center | Rochester | New York | 14642 | United States |
| Cleveland Clinic | Cleveland | Ohio | 44195 | United States |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | United States |
| ID | Term |
|---|---|
| D000099067 | Blastic Plasmacytoid Dendritic Cell Neoplasm |
| D015451 | Leukemia, Lymphocytic, Chronic, B-Cell |
| D012008 | Recurrence |
| D007943 | Leukemia, Hairy Cell |
| D016403 | Lymphoma, Large B-Cell, Diffuse |
| ID | Term |
|---|---|
| D015620 | Histiocytic Disorders, Malignant |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D007938 | Leukemia |
| D008223 | Lymphoma |
| D019337 | Hematologic Neoplasms |
| D009371 | Neoplasms by Site |
| D012878 | Skin Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D015448 | Leukemia, B-Cell |
| D007945 | Leukemia, Lymphoid |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016393 | Lymphoma, B-Cell |
| D008228 | Lymphoma, Non-Hodgkin |
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