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Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung cancer patient | Lung cancer patients or lung cancer survivors willing to refer close contacts for lung cancer screening | ||
| Referred participants | Participants referred to the study by close contacts living with lung cancer. |
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| Measure | Description | Time Frame |
|---|---|---|
| Mean number of referrals for lung cancer screening per participants | Mean number of referrals for lung cancer screening per participants: lung cancer participants will refer contacts directly on the REDCap questionnaire at enrollment. They will be contacted a second time 2 weeks after enrollment and asked if they referred additional people in their entourage for lung cancer screening. | 2 weeks post inclusion |
| Mean PLCOm2012 risk prediction model score among referred participants | Mean risk of developing lung cancer in the next 6 years using the validated PLCOm2012 risk prediction model in smokers or ex-smokers referred participants that are 55 to 74 years old. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Number of visitors on our website for referred participants | Quantification of people who visited the website for close contacts of lung cancer patients: Number of unique access to website based on google analytics data. | 6 months |
| Number of people who started to fill the enrollment form for referred participants. |
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Lung cancer patients:
Inclusion Criteria:
Exclusion Criteria: none
Referred participants Inclusion criteria: >18 years old Exclusion criteria: Personal history of lung cancer.
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| Name | Affiliation | Role |
|---|---|---|
| Nicole Ezer, MD | Research Institute of the McGill University Health Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MUHC | Montreal | Quebec | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40153794 | Derived | Pitrou I, Petrangelo A, Besson C, Pepe C, Waschke AH, Agulnik J, Gonzalez AV, Ezer N. Lung Cancer Screening in Family Members and Peers of Patients With Lung Cancer: Protocol for a Prospective Cohort Study. JMIR Res Protoc. 2025 Mar 28;14:e58529. doi: 10.2196/58529. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D010358 | Patient Participation |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Number of people who started to fill the enrollment form for referred participants. |
| 6 months |
| Number of referred participants who enrolled in the study. | Number of referred participants who enrolled in the study. | 6 months |
| PLCO score as a binary outcome (above or below 2%) among referred participants | baseline |
| Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient | Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient | 18 months |
| Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk. | Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk. | baseline |
| Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers | Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers | baseline |
| Anxiety regarding lung cancer for referred participants | GAD7 | baseline |
| Anxiety regarding lung cancer for referred participants | GAD7 | 1 month |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |