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Recent researches have reported that biologics might be also effective for stricturing CD. However, the data were largely retrospective. Prospective studied are needed for evaluate the efficacy of biologics for stricturing Crohn's diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with stricturing Crohn's diseases | Patients with stricturing Crohn's diseases |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| treat these patients with biologics | Other | treat these patients with biologics |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical remission rate at 1 year | clinical remission rate at 1 year (CDAI less than 150) | clinical remission rate at 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| clinical remission rate at 5 year | clinical remission rate at 5 year (CDAI less than 150) | clinical remission rate at 5 year |
| surgical recurrence rate at 1 and 5 year | surgical recurrence : needing surgery for CD recurrence |
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Inclusion Criteria:
Exclusion Criteria:
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200
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Weiming wm Zhu, Ph.D. | Contact | +86-025-80863736 | 860736 | juwiming@nju.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Weiming wm Zhu, Ph.D. | Jinling Hospital, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of General Surgery, Jinling hosptal,Medical School of Nanjing University | Recruiting | Nanjing | Jiangsu | 210002 | China |
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| ID | Term |
|---|---|
| D001688 | Biological Products |
| ID | Term |
|---|---|
| D045424 | Complex Mixtures |
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| at 1 and 5 year |
| endoscopic recurrence rate at 1 and 5 year | endoscopic recurrence: rutgeerts over i2b | at 1 and 5 year |
| quality of life of patients assessed by IBDQ | IBDQ | at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year |
| quality of life of patients assessed by Short form 12 | Short form 12 | at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year |
| score of obstructive | range 0-6, higher means severe | at 2, 4, 6 , 8 months and at 1, 2, 3, 4 and 5 year |