Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.

This research study will (1) test the ability of a new electronic camera developed in Dr. Miller's laboratory to observe retina in human subjects, and (2) use the camera for observing disease in the eye. This new camera integrates cutting-edge technologies in adaptive optics (AO) and optical coherence tomography (OCT) that enable the camera to capture sharp images. The objective of our study is to find out (1) whether the AO-OCT camera will allow researchers to observe the retina with finer resolution than current clinical cameras, and (2) whether this finer detail is useful for observing the progression of disease in the eye.

To address the second objective, the study will subjects with various disease severity of drusen associated geographic atrophy.

Inclusion Criteria:

• Retinal disease of either inherited retinal degeneration or retinal toxicity

Exclusion Criteria:

• Ocular media opacities
• High refractive error
• Pupil dilation imposes a risk to ocular health