The aim of the study is to understand the structural and functional modifications of the host, the microorganisms, and their interactions (host/microorganism relationship) before and after the RV3278A - ET0943 product application

Inclusion Criteria:

1. Related to the population:

   - Subject aged between 12 to 25 years included

2. Related to diseases:

   • Subject having acne lesions on the face, with GEA (Global Acne Evaluation) score on the face is assessed as 2 (mild) or as 3 (moderate), on a scale ranged from 0 (clear- no lesion) to 5 (very severe)
   • Subject having at least 20 open-comedones of about 1 mm in diameter on the face and possibly extractable
   • Subject having a predominance of non-inflammatory acne lesions

Exclusion Criteria:

1. Related to diseases:

   • Subject having comedones only on the nose wings
   • Subject with any other dermatological disease than acne or skin characteristics (like scar, tatoo) on the face liable to interfere with the study according to the investigator's assessment
   • Subject with an acute or chronic disease, or history of disease liable to interfere with the study data or considered by the Investigator hazardous for the subject or incompatible with the study requirements
   • Severe form of acne (Acne conglobata, Acne fulminans or nodulokystic acne) or acneiform induced rashes according to the investigator's assessment
   • Clinical signs of a hormonal dysfunction or of a hyperandrogenism
   • Solar erythema on the face due to excessive UV exposur

2. Related to the treatments/products:

   • Any previous/concomitant treatment or product considered by the Investigator liable to interfere with the study data or incompatible with the study requirements or hazardous for the subject

Subjects are enrolled during their usual medical care and/or from the database of the investigational sites.

The subjects corresponding to eligibility criteria may receive a phone call, a letter or an e-mail proposing to participate to the study.