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The goal of this observational study is to compare in ICU patients received CVVH treatment. The main questions it aims to answer are:
Control of Filtration fraction by built-in calculator
Researchers will compare before group to see if there were differences in clotting events, filter downtime, filter lifespan, mortality, etc.
# built-in calculator for calculating Filtration fraction
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Before group |
| ||
| After group |
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Built-in calculator to calculate Filtration fraction | Device | A calculator built in electronic CVVH prescription system to calculate Filtration fraction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Patient death | 30 days, 60 days, "through study completion, an average of 1.5 year" mortality in ICU and in Hospital |
| Measure | Description | Time Frame |
|---|---|---|
| Filter clotting events | Filter clotting events | "through the complete treatment course hours, an average of 24 hours" |
| Filter lifespan | average treatment time per filter |
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Inclusion Criteria:
Exclusion Criteria:
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ICU patients received CVVH during 2019~2021 (3 years) in our hospital, and excluded patients under age of 20, pregnant, or with HIV infection
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shuang-Ho Hospital | New Taipei City | Zhonghe District | 23561 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22890468 | Result | Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179-84. doi: 10.1159/000339789. Epub 2012 Aug 7. No abstract available. | |
| 19426422 | Result | Davenport A. Continuous renal replacement therapies in patients with acute neurological injury. Semin Dial. 2009 Mar-Apr;22(2):165-8. doi: 10.1111/j.1525-139X.2008.00548.x. |
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there is currently no plan to make individual participant data (IPD) available to other researchers
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| "through the complete treatment course hours, an average of 24 hours" |
| electrolytes_1 | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) |
| electrolytes_2 | K | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) |
| electrolytes_3 | Ca | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) |
| electrolytes_4 | P | the last record received before CVVH (in an average of 1 hour), the first record received CVVH after 24 hours, the first record received after CVVH (in an average of 1 hour) |
| acid-base balance_1 | pH | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) |
| acid-base balance_2 | bicarbonate | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) |
| Filter downtime | downtime between filter replacement | "through the complete treatment course hours, an average of 24 hours" |
| others_1 | body temperature | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) |
| others_2 | platelet | the last record received before CVVH (in an average of 1 hour before CVVH treatment), the first record received CVVH after 24 hours (in an average of 1 hour after CVVH treatment), the first record received after CVVH (in an average of 1 hour after CVVH) |
| 17636735 | Result | Rabindranath K, Adams J, Macleod AM, Muirhead N. Intermittent versus continuous renal replacement therapy for acute renal failure in adults. Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD003773. doi: 10.1002/14651858.CD003773.pub3. |
| 30247213 | Result | Wang AY, Bellomo R. Renal replacement therapy in the ICU: intermittent hemodialysis, sustained low-efficiency dialysis or continuous renal replacement therapy? Curr Opin Crit Care. 2018 Dec;24(6):437-442. doi: 10.1097/MCC.0000000000000541. |
| 32144519 | Result | Karkar A, Ronco C. Prescription of CRRT: a pathway to optimize therapy. Ann Intensive Care. 2020 Mar 6;10(1):32. doi: 10.1186/s13613-020-0648-y. |
| 35337352 | Result | Tsujimoto Y, Fujii T. How to Prolong Filter Life During Continuous Renal Replacement Therapy? Crit Care. 2022 Mar 22;26(1):62. doi: 10.1186/s13054-022-03910-8. |
| 32164041 | Result | Tsujimoto H, Tsujimoto Y, Nakata Y, Fujii T, Takahashi S, Akazawa M, Kataoka Y. Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2020 Mar 13;3(3):CD012467. doi: 10.1002/14651858.CD012467.pub2. |
| 34519356 | Result | Tsujimoto Y, Miki S, Shimada H, Tsujimoto H, Yasuda H, Kataoka Y, Fujii T. Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2021 Sep 14;9(9):CD013330. doi: 10.1002/14651858.CD013330.pub2. |
| 17634148 | Result | Joannidis M, Oudemans-van Straaten HM. Clinical review: Patency of the circuit in continuous renal replacement therapy. Crit Care. 2007;11(4):218. doi: 10.1186/cc5937. |
| 28979457 | Result | Cottle D, Mousdale S, Waqar-Uddin H, Tully R, Taylor B. Calculating evidence-based renal replacement therapy - Introducing an excel-based calculator to improve prescribing and delivery in renal replacement therapy - A before and after study. J Intensive Care Soc. 2016 Feb;17(1):44-50. doi: 10.1177/1751143715603383. Epub 2015 Sep 21. |
| 31540789 | Result | Griffin BR, Thomson A, Yoder M, Francis I, Ambruso S, Bregman A, Feller M, Johnson-Bortolotto S, King C, Bonnes D, Dufficy L, Wu C, Bansal A, Tad-Y D, Faubel S, Jalal D. Continuous Renal Replacement Therapy Dosing in Critically Ill Patients: A Quality Improvement Initiative. Am J Kidney Dis. 2019 Dec;74(6):727-735. doi: 10.1053/j.ajkd.2019.06.013. Epub 2019 Sep 17. |
| 33244053 | Result | Ruiz EF, Ortiz-Soriano VM, Talbott M, Klein BA, Thompson Bastin ML, Mayer KP, Price EB, Dorfman R, Adams BN, Fryman L, Neyra JA; University of Kentucky CRRT Quality Assurance Group. Development, implementation and outcomes of a quality assurance system for the provision of continuous renal replacement therapy in the intensive care unit. Sci Rep. 2020 Nov 26;10(1):20616. doi: 10.1038/s41598-020-76785-w. |
| 29984198 | Result | Honore PM, Spapen HD. What a Clinician Should Know About a Renal Replacement Membrane? J Transl Int Med. 2018 Jun 26;6(2):62-65. doi: 10.2478/jtim-2018-0016. eCollection 2018 Jun. No abstract available. |
| 27113697 | Result | Yessayan L, Yee J, Frinak S, Szamosfalvi B. Continuous Renal Replacement Therapy for the Management of Acid-Base and Electrolyte Imbalances in Acute Kidney Injury. Adv Chronic Kidney Dis. 2016 May;23(3):203-10. doi: 10.1053/j.ackd.2016.02.005. |
| 20308999 | Result | Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010 May;6(5):274-85. doi: 10.1038/nrneph.2010.33. Epub 2010 Mar 23. |
| 12602465 | Result | Rocktaschel J, Morimatsu H, Uchino S, Ronco C, Bellomo R. Impact of continuous veno-venous hemofiltration on acid-base balance. Int J Artif Organs. 2003 Jan;26(1):19-25. doi: 10.1177/039139880302600104. |
| 33389356 | Result | Leypoldt JK, Pietribiasi M, Echeverri J, Harenski K. Modeling acid-base balance during continuous kidney replacement therapy. J Clin Monit Comput. 2022 Feb;36(1):179-189. doi: 10.1007/s10877-020-00635-3. Epub 2021 Jan 3. |