To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions.

Inclusion Criteria:

• Persons 18 to 85 years of age at the date of informed consent.
• If presenting with a history of a specific condition, the diagnosis is confirmable in the medical record or may be confirmed using other forms of verification including self-reporting.
• Understands the procedures and requirements of the study by providing written informed consent (or verbal assent if a legally authorized representative will sign the ICF), including consent for authorization for protected health information disclosure.

Exclusion Criteria:

• Persons younger than 18 years of age or older than 85 years of age at the date of informed consent.
• Receipt of blood products 30 days before the study blood draw.
• Receipt of an investigational (unapproved) drug 30 days before the study blood draw.
• A confirmable diagnosis of any medical condition that would increase potential phlebotomy risks.
• Has donated a unit of blood within the last 2 months at the date of informed consent.

Health condition, exceptive condition, and control participants will be recruited by one or any of the following resources, but not limited to:

• Use of online marketing where potential participants receive study information from the Sanguine's website or online participant referral program;
• In the site investigators (or PI's) clinic; and/or
• Through community advocacy programs.
• Participant Referral