The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children with Moderate Persistent Asthma

Inclusion Criteria:

• Children with moderate persistent asthma
• Age range of 8-< 18 years old
• Both sex

Exclusion Criteria:

• Children with any pulmonary or chronic systemic diseases other than asthma (cystic fibrosis, bronchiectasis, tuberculosis, diabetes mellitus, and liver disease).
• Children with immunodeficiency.
• Children with thyroid disorder.
• Children with recent infection (especially pneumonia), surgery, anesthesia.
• Children having clinical evidence of any heart renal and hepatic diseases.
• Children having cystic fibrosis or congenital respiratory disease.
• Children having chronic diarrhea and mal-absorption.
• Children having clinical evidence of malnutrition.
• Children on medications that could interfere with L-carnitine level including antibiotics use. (particularly ampicillins) and anti- convulsing particularly valoproic acid.