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In this study; during the oocyte retrieval procedure, it was aimed to compare two different general anesthesia methods, in which propofol was administered as infusion according to the patient's Bispectral index system (BIS) value or in bolus doses according to the patient's clinic.The hypothesis of the study; during the oocyte retrieval process, when propofol is administered as an infusion and accompanied by BIS monitoring, adequate anesthesia level will be achieved with less amount of bolus doses according to the clinical condition of the patient.
130 patients over the age of 18, ASA I-II, who underwent oocyte retrieval for IVF treatment were included in the study. The patients divided into two groups. In induction, 2mg/kg fentanyl, 40mg lidocaine and 2mg/kg propofol administered to all patients. Patients in group 1; propofol added in bolus doses of 0.5mg/kg. Doses determined according to the clinical condition of the patient. Patients in group 2; propofol administered as 10mg/kg/hour infusion. The infusion dose adjusted so that the Bispectral index (BIS) is in the range of 40-60.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group bolus | Active Comparator | Propofol will be administered in bolus doses of 0.5mg/kg. Doses will be determined according to the clinical condition of the patient. |
|
| Group infusion | Active Comparator | Propofol will be administered as 10mg/kg/hour infusion. The infusion dose will be adjusted so that the Bispectral index (BIS) is in the range of 40-60. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| propofol bolus | Drug | Propofol will be added in bolus doses of 0.5mg/kg. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Propofol | The total amount of Propofol (mg) administered during the procedure | up to 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Observer's assessment of sedation scale (OSS) | Time to reach 5 on the observer's assessment of sedation scale of the patients | up to 1 hour |
| (Post Anesthetic Discharge Scoring System) PADSS | Time of patients to reach PADSS ≥ 9 (Min:0 and Max: 10) PADSS ≥ 9 is suitable for discharge of the patient |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sevgi Bilgen | Acibadem University, Acibadem Kozyatagi Hastanesi | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acibadem Kozyatagi Hastanesi | Istanbul | 34742 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38057377 | Derived | Bilgen S, Erdogan D, Okten SB. Infusion of propofol with bispectral index monitoring does not reduce the amount of propofol used during transvaginal oocyte retrieval procedure. Sci Rep. 2023 Dec 6;13(1):21561. doi: 10.1038/s41598-023-48611-6. |
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| propofol infusion |
| Drug |
Propofol will be administered as 10mg/kg/hour infusion. |
|
| up to 6 hour |
| (Satisfaction of patients) STF 1 | Patient satisfaction (The scale is in the range of 1-4. 1: the best) | up to 6 hour |
| (Satisfaction of gynecologist) STF 2 | Satisfaction of the doctor performing the procedure(The scale is in the range of 1-4. 1: the best) | up to 1 hour |