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| ID | Type | Description | Link |
|---|---|---|---|
| 19200171 | Other Grant/Funding Number | Health and Medical Research Fund |
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| Name | Class |
|---|---|
| Health and Medical Research Fund | OTHER_GOV |
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The goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression. It is hypothesized that the self-administered acupressure group would have a great improvement in depressive symptoms as measured by the Patient Health Questionnaire compared with the mental health education group across the 12-week intervention period.
The main questions it aims to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Self-administered acupressure group | Experimental | The participants in the self-administered acupressure group will attend an acupressure training course (2 sessions, 2 h each) to learn self-administered acupressure from an acupuncturist in a classroom at the School Nursing, the Hong Kong Polytechnic University. Each class will be conducted in a small group of 4 to 7 participants to enhance interaction and ensure the quality of teaching. Participants will then practice two times a day for 8 weeks. |
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| Mental health education group | Active Comparator | The participants in the comparison group will receive mental health education group from a registered nurse with the same frequency as those in the treatment group (2 sessions, 2 h each) in a classroom at the School Nursing, the Hong Kong Polytechnic University, and will be reminded to follow the mental health practice daily for 8 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Self-administered acupressure group | Behavioral | Self-administered acupressure treatment group was developed on the basis of previous systematic reviews and clinical studies of acupuncture and acupressure for depression. It has robust theoretical basis of TCM. The acupoints selected are commonly used for depression according to a recent systematic review and recommended by other clinical practice guidelines. |
| Measure | Description | Time Frame |
|---|---|---|
| Patient Health Questionnaire (PHQ) | The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27. | It will be measured at baseline |
| Patient Health Questionnaire (PHQ) | The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27. | It will be measured at week 4 from baseline |
| Patient Health Questionnaire (PHQ) | The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27. | It will be measured at week 8 from baseline |
| Patient Health Questionnaire (PHQ) | The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27. | It will be measured at week 12 from baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Hamilton Depression Rating Scale (HDRS) | The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression. | It will be measured at baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wing Fai Yeung, PhD | Contact | 852 2766 4151 | jerry-wf.yeung@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Wing Fai Yeung, PhD | the School of Nursing, the Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Nursing, the Hong Kong Polytechnic University | Recruiting | Hong Kong | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34623754 | Background | Zhang Z, Li S, Meng H, Wang Y, Zhang Y, Wu M, Chen Y, Rong P, Wang Y. Efficacy and safety of acupuncture in the treatment of depression: A systematic review of clinical research. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. | |
| 32147048 | Background | Fernandez-Chinguel JE, Goicochea-Lugo S, Villarreal-Zegarra D, Taype-Rondan A, Zafra-Tanaka JH. Acupuncture for major depressive disorder: A review of the recommendations stated at clinical practice guidelines. Complement Ther Med. 2020 Mar;49:102321. doi: 10.1016/j.ctim.2020.102321. Epub 2020 Jan 24. |
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The individual participant data will be available when the study has been published. The individual participant data will be available upon request.
No time restriction for the data availability.
The individual participant data will be available upon request.
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| ID | Term |
|---|---|
| D003863 | Depression |
| D003866 | Depressive Disorder |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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Two-arm parallel assignment involves two groups of participants. In this study, one group will receive self-administered acupressure, and the other group will receive the mental health education. So during the trial, participants in one group receive self-administered acupressure "in parallel" to participants in the other group, who receive the mental health education.
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The researchers who perform the assessment and analysis will be blinded to group allocation.
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| Mental health education group | Behavioral | Mental health education training group was developed based on the materials regarding depression and mental health from the Centre of Health Protection, Department of Health, the Government of Hong Kong SAR and reviewed by a clinical psychologist. |
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| Hamilton Depression Rating Scale (HDRS) | The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression. | It will be measured at week 4 from baseline |
| Hamilton Depression Rating Scale (HDRS) | The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression. | It will be measured at week 8 from baseline |
| Hamilton Depression Rating Scale (HDRS) | The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression. | It will be measured at week 12 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Stress | The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Stress | The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 4 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Stress | The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 8 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Stress | The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 12 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Anxiety | The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Anxiety | The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 4 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Anxiety | The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 8 from baseline |
| The Depression Anxiety Stress Scales (DASS-21) - Anxiety | The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always). | It will be measured at week 12 from baseline |
| The Insomnia Severity Index (ISI) | The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale. | It will be measured at baseline |
| The Insomnia Severity Index (ISI) | The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale. | It will be measured at week 4 from baseline |
| The Insomnia Severity Index (ISI) | The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale. | It will be measured at week 8 from baseline |
| The Insomnia Severity Index (ISI) | The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale. | It will be measured at week 12 from baseline |
| The Short-Form (six-dimension) Health Survey (SF-6D) | The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life. | It will be measured at baseline |
| The Short-Form (six-dimension) Health Survey (SF-6D) | The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life. | It will be measured at week 4 from baseline |
| The Short-Form (six-dimension) Health Survey (SF-6D) | The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life. | It will be measured at week 8 from baseline |
| The Short-Form (six-dimension) Health Survey (SF-6D) | The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life. | It will be measured at week 12 from baseline |
| 32096884 | Background | Cheung DST, Tiwari A, Yeung WF, Yu DSF, So MKP, Chau PH, Wang XM, Lum TYS, Yuk Fung HYK, Ng BYM, Zhang ZJ, Lao L. Self-Administered Acupressure for Caregivers of Older Family Members: A Randomized Controlled Trial. J Am Geriatr Soc. 2020 Jun;68(6):1193-1201. doi: 10.1111/jgs.16357. Epub 2020 Feb 25. |
| 22231681 | Background | Kroenke K. Enhancing the clinical utility of depression screening. CMAJ. 2012 Feb 21;184(3):281-2. doi: 10.1503/cmaj.112004. Epub 2012 Jan 9. No abstract available. |
| 42339308 | Derived | Yeung WF, Yu BYM, Ho FY, Wong CKH, Chung KF, Ruan JY, Chen S, Cheung DST, Zhang ZJ, Zick S, Cheng H, Ho YS, Ho LM, Lao L. Self-administered acupressure training for depression in community-dwelling individuals: a randomized controlled trial and cost-effectiveness analysis. EClinicalMedicine. 2026 Jun 16;96:104023. doi: 10.1016/j.eclinm.2026.104023. eCollection 2026 Jun. |