Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to test a newer type of high intensity interval resistance training in adults 65 years of age or older. The main aims of this study are:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stretching, Balance, Range of Motion | Active Comparator | Participants will engage stretching, balance, and range of motion exercises 2 days per week for 12-weeks. |
|
| High Intensity Interval Resistance Training | Experimental | Participants will perform resistance training exercises at high intensity intervals 2 days per week for 12-weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Intensity Interval Resistance Training | Behavioral | During each group exercise session, the participants will be guided through a 5-minute warm-up, supervised to perform two sets of machine-based leg press, chest press, seated row, and shoulder press exercises at 30% of 1-RM, and guided through a cool-down. Each exercise set will be 40 -seconds in length with instructions to perform as many repetitions as possible followed by a 20-second rest in between sets and a three-minute rest between exercises. |
| Measure | Description | Time Frame |
|---|---|---|
| Executive Functioning | Executive Functioning will be operationalized as an index of several computer-based tasks assessing aspects of executive functioning: Inhibition (Stroop Test), Updating (The 4-part continuous performance task), and Switching (Shifting attention task, Symbol Digit Coding). | Baseline and 12-weeks |
| Gradual Continuous Performance Test | Participants will make continuous responses to target picture stimuli (images of cities among distractor images of mountains). Periodically, a colored border will appear around each location, cuing the participant to attend to either the left or right picture stream. If the currently cued stream differs from their previous focus of attention, the participant will make a saccadic eye movement. At the same time as the color onset, a number will appear at each location. Participants will then make an even/odd discrimination for stimuli appearing at the to-be-attended location. | Baseline and 12-weeks |
| Functional Magnetic Resonance Imagining | Participants will complete a 60-minute magnetic resonance imagining session during which will acquire a high-resolution anatomical scan, an echo planar image while participants complete the Gradual Continuous Performance Test. This task is a cognitive task designed to measure the neural correlates of moment-by-moment fluctuations in the efficacy of sustained attention and attention shifting readiness, termed attentional flexibility, a resting state scan, and a diffusion tensor imaging to measure white matter tract integrity. | Baseline and 12-weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Brain Derived Neurotrophic Factor | Blood will be drawn using venipuncture to collect a serum sample. A blood analysis will be performed to examine brain derived neurotrophic factor, a marker suggesting an increase hippocampal neural growth. | Baseline and 12-weeks |
| The Physical Activity Enjoyment Scale |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jeffery A Katula, Ph.D | Contact | (336) 758-3612 | katulaj@wfu.edu | |
| Anthony Sali, Ph.D | Contact | (336) 758-4813 | saliaw@wfu.edu |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D016059 | Range of Motion, Articular |
| ID | Term |
|---|---|
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D009142 | Musculoskeletal Physiological Phenomena |
Not provided
Not provided
Randomized Control Trial
Not provided
Not provided
Not provided
Not provided
|
| Stretching, Balance, and Range of motion | Behavioral | The stretching, balance, and range of motion intervention will include a rotating and varied routine of stretching exercises for large and small muscle groups, and activities to improve balance and range of motion. Participants will attend this intervention twice a week with each session lasting 30 minutes. |
|
The physical activity enjoyment scale captures the extent to which an individual enjoys the physical activities they are currently participating in. The individual is asked to respond to 18 items with bipolar anchors on a 7-point Likert-type scale (e.g., 1=I enjoy it, 7=I hate it; 1=I feel bored, 7=I feel interested). |
| Baseline and 12-weeks |
| Community Health Activities Model Program for Seniors Activity Questionnaire for Older Adults | This physical activity questionnaire tasks participants with reporting the extent to which they participated in various occupational, transport, leisure time, and home physical activities in the previous 4 weeks (e.g., "In a typical or normal week during the past 4 weeks, did you do heavy gardening?"). If the participant indicates "yes" they next indicate the weekly frequency and duration of the activity. Following scoring, the scale produces variables capturing average weekly frequency, duration, and caloric expenditure for both total physical activity and exercise-specific activities. | Baseline and 12-weeks |
| Basic Psychological Need Satisfaction and Frustration Scales | he BPNSFS reflect the extent to which an individual experiences satisfaction and frustration in achieving the core human needs of relatedness, competence, and autonomy. Participants respond to 24 questions (e.g., "I feel a sense of choice and freedom in the things I undertake") on a 5-point Likert-type scale where 1 indicates "Not True at All" and 5 indicates "Completely True". The scale produces 6 subscale scores, including both frustration and satisfaction subscales for autonomy, competence, and satisfaction. Each subscale is computed as the sum of four questionnaire items, with scores ranging from 4-20, with higher scores reflecting greater satisfaction or frustration. | Baseline and 12-weeks |
| SF-36 Health Questionnaire | The SF-36 is a generic measure of health status/health-related quality of life that consists of two norm-based composite T-scales, mental health and physical function, and 8 subscales: physical functioning, mental health, role-physical, role-emotional, bodily pain, general health, vitality, and social functioning. | Baseline and 12-weeks |
| 400 Meter Walk Test | The 400 meter walk test assesses walking speed and endurance in older adults on a 20 meter course. The timed walk covers 10 laps totaling 400 meters. | Baseline and 12-weeks |
| Short Physical Performance Battery | This measure assesses lower extremity functioning. | Baseline and 12-weeks |
| Stroop Test | This is a three part test. Participants will be asked to respond the words "RED", "GREEN", "YELLOW", "BLUE", and "GREEN" in different colors according to the instructions provided for each part. | Baseline and 12-weeks |
| Symbol Digit Coding | The symbol digit coding test measures complex information processing accuracy, complex attention, visual-perceptual speed, and information processing speed. | Baseline and 12-weeks |
| Four-Part Continuous Performance Test | The four-part continuous performance is a test that measures the participant's working memory and sustained attention. | Baseline and 12-weeks |
| Shifting Attention Test | The shifting attention test is a measure of ability to shift from one instruction set to another quickly and accurately. Participants will be instructed to match geometric objects either by shape or by color. | Baseline and 12-weeks |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |