To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

Inclusion Criteria:

• duration of invasive mechanical ventilation less than 72 hours;
• meet the diagnostic criteria of Berlin definition for ARDS;
• age older than 18

Exclusion Criteria:

• esophageal surgery or damage;
• cardiac surgery;
• severe bronchopleural fistula;
• serious arrhythmia; pneumothorax;
• tricuspid stenosis;
• heparin allergy;
• chronic pulmonary heart disease