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| Name | Class |
|---|---|
| University College London Hospitals | OTHER |
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There are two parts to this study:
Eating a healthy, balanced diet is important for health. A healthy, balanced diet involves eating a variety of foods in the right proportions. In the UK, the Eatwell Guide gives recommendations on what people should eat more of, and what people should eat less of. Unhealthy diets contain lots of foods high in saturated fat, added sugar and salt, which increases the risk of developing obesity, cardiovascular disease and type 2 diabetes. Advice for a healthy, balanced diet includes consuming five portions of fruit and vegetables per day and eating more high fibre foods. Following the healthy, balanced diet advice given in the Eatwell Guide can reduce the risk of poor health.
However, there are other parts of the diet that are not covered in the Eatwell Guide that may also be important for health. For example, research suggests that different types of food processing might influence health, but these types of food processing are not included within the recommendations.
It is unknown if the benefits of following the healthy diet advice in the Eatwell Guide depend on the types of food processing in the diet. It is important to find out if these types of food processing matter, in order to give people the best advice possible. It also means that the government and other health organisations may need to change the regulations around the food that people eat.
To answer this, the investigators will compare the effects of two healthy, balanced diets following the advice in the UK Eatwell Guide, but each based on a different type of food processing (referred to in this study as Diet A and Diet B to avoid unblinding). Participants will receive the first diet for 8 weeks, return to their normal diet for 4 weeks, and then receive the second diet for a further 8 weeks. Participants will have 6 months of support to help improve their diet and be more physically active. Participants will work with a behavioural scientist to create a personal plan to eat a healthier diet and be more physically active, using behaviour change techniques based on capability, opportunity, motivation - behaviour (COM-B) theory of behaviour change. This support will last for 6 months, with ongoing monthly telephone/video calls with the research team. The results from this study will be used to help inform UK dietary guidance and food policy.
There are two parts to this study:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diet A then Diet B, followed by a 6-month behavioural support programme | Experimental | 8-weeks of Diet A then 8-weeks of Diet B, then 6 months of goal-based behavioural support for consuming a healthy, balanced diet, increasing physical activity and reducing sedentary behaviour. |
|
| Diet B then Diet A, followed by a 6-month behavioural support programme | Experimental | 8-weeks of Diet B then 8-weeks of Diet A, then 6 months of goal-based behavioural support for consuming a healthy, balanced diet, increasing physical activity and reducing sedentary behaviour. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Healthy, balanced Diet A | Dietary Supplement | Healthy, balanced diet following Eatwell Guide recommendations |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean difference in percent weight change (%WC) at 8 weeks between Diet A and Diet B | %WC will be calculated using: %WC = ((weight at baseline - weight at timepoint after baseline)/weight at baseline) x 100, calculated at each intervention endpoint. Mean difference in percent weight change will be calculated as: percent weight change diet A - percent weight change diet B. Weight measured in kilograms. | Baseline to 8 weeks for both diets |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in waist circumference at 8 weeks between Diet A and Diet B | Assessed using a tape measure | Baseline to 8 weeks for both diets |
| Changes in waist circumference after 6-months of the behavioural support programme |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rachel L Batterham, Professor | UCL, UCL Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCL | London | WC1E 6JF | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41161844 | Derived | Heuchan GN, Buck C, Conway R, Dicken S, Brown AC, Jassil FC, Makaronidis J, Van Tulleken C, Gandini Wheeler-Kingshott CA, Batterham R, Fisher A. Development, content and planned evaluation of a behavioural support intervention to reduce ultraprocessed food intake and increase physical activity in UK healthcare workers: UPDATE trial stage 2 study protocol. BMJ Open. 2025 Oct 29;15(10):e107435. doi: 10.1136/bmjopen-2025-107435. | |
| 40760353 |
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2x2, randomised, controlled crossover trial
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To minimise unnecessary unblinding, participants will not be informed of the order in which they receive their diets, but it will likely become clear which diet they are consuming, and thus the study will not be considered to be blinded.
| Healthy, balanced Diet B | Dietary Supplement | Healthy, balanced diet following Eatwell Guide recommendations |
|
| Behavioural support intervention | Behavioral | Participants will work with a behavioural scientist to create a personal plan to eat a healthier diet and be more physically active. This support will last for 6 months, with ongoing monthly telephone/video calls with the research team. |
|
Assessed using a tape measure
| First baseline to 6-months follow-up |
| Changes in fat-free mass at 8 weeks between Diet A and Diet B | Assessed using bioelectrical impedance analysis (BIA) | Baseline to 8 weeks for both diets |
| Changes in fat-free mass after 6-months of the behavioural support | Assessed using bioelectrical impedance analysis (BIA) | First baseline to 6-months follow-up |
| Changes in fat mass at 8 weeks between Diet A and Diet B | Assessed using bioelectrical impedance analysis (BIA) | Baseline to 8 weeks for both diets |
| Changes in fat mass after 6-months of the behavioural support | Assessed using bioelectrical impedance analysis (BIA) | First baseline to 6-months follow-up |
| Changes in heart rate at 8 weeks between Diet A and Diet B | Assessed using an oximeter | Baseline to 8 weeks for both diets |
| Changes in heart rate after 6-months of the behavioural support | Assessed using an oximeter | First baseline to 6-months follow-up |
| Changes in systolic and diastolic blood pressure at 8 weeks between Diet A and Diet B | Assessed using a sphygmomanometer | Baseline to 8 weeks for both diets |
| Changes in systolic and diastolic blood pressure after 6-months of the behavioural support | Assessed using a sphygmomanometer | First baseline to 6-months follow-up |
| Changes in comorbidities at 8 weeks between Diet A and Diet B | Comorbidities assessed using medical records, physical examination and blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in Liver function at 8 weeks between Diet A and Diet B | Fasted Liver function assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in Glucose at 8 weeks between Diet A and Diet B | Fasted Glucose assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in Lipids at 8 weeks between Diet A and Diet B | Fasted Lipids assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in HbA1c at 8 weeks between Diet A and Diet B | Fasted HbA1c assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in C-reactive protein (CRP) at 8 weeks between Diet A and Diet B | Fasted CRP assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in metabolomics at 8 weeks between Diet A and Diet B | Fasted and fed metabolomics assessed using blood sample analyses | Baseline to 8 weeks for both diets |
| Changes in Comorbidities after 6-months of the behavioural support | Comorbidities assessed using medical records, physical examination and blood sample analyses | First baseline to 6-months follow-up |
| Changes in Liver function after 6-months of the behavioural support | Fasted Liver function assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in Glucose after 6-months of the behavioural support | Fasted Glucose assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in metabolomics after 6-months of the behavioural support | Fasted and fed metabolomics assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in Lipids after 6-months of the behavioural support | Fasted Lipids assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in HbA1c after 6-months of the behavioural support | Fasted HbA1c assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in C-reactive protein (CRP) after 6-months of the behavioural support | Fasted CRP assessed using blood sample analyses | First baseline to 6-months follow-up |
| Changes in appetite at 8 weeks between Diet A and Diet B | Fasted and fed appetite scores (Visual analogue scale) assessed using a meal test | Baseline to 8 weeks for both diets |
| Changes in gut hormones at 8 weeks between Diet A and Diet B | Fasted and fed circulating gut hormones assessed using a meal test | Baseline to 8 weeks for both diets |
| Changes in adipocytokines at 8 weeks between Diet A and Diet B | Fasted adipocytokines assessed using a meal test | Baseline to 8 weeks for both diets |
| Changes in appetite after 6-months of the behavioural support | (a) Fasted and fed appetite scores (Visual analogue scale, 10 point scale, higher score indicates greater hunger) assessed using a meal test | First baseline to 6-months follow-up |
| Changes in gut hormones after 6-months of the behavioural support | Fasted and fed circulating gut hormones assessed using a meal test | First baseline to 6-months follow-up |
| Changes in adipocytokines after 6-months of the behavioural support | Fasted adipocytokines assessed using a meal test | First baseline to 6-months follow-up |
| Changes in sleep at 8 weeks between Diet A and Diet B | Change in objectively reported sleep assessed using accelerometry. | Baseline to 8 weeks for both diets |
| Changes in sleep quality at 8 weeks between Diet A and Diet B | Change in subjectively reported sleep assessed using the Pittsburgh Sleep Quality Index The Pittsburgh Sleep Quality Index is a validated 19-item measure, which will be used to determine sleep quality in the past month, to distinguish between good and poor sleepers. A higher score indicates poorer sleep quality. | Baseline to 8 weeks for both diets |
| Changes in sleep after 6-months of the behavioural support | Change in objectively reported sleep assessed using accelerometry. | First baseline to 6-months follow-up |
| Changes in sleep quality after 6-months of the behavioural support | Change in subjectively reported sleep assessed using the Pittsburgh Sleep Quality Index The Pittsburgh Sleep Quality Index is a validated 19-item measure, which will be used to determine sleep quality in the past month, to distinguish between good and poor sleepers. A higher score indicates poorer sleep quality. | First baseline to 6-months follow-up |
| Changes in physical activity at 8 weeks between Diet A and Diet B | (a) Change in objectively reported physical activity levels (sedentary, light (LPA), moderate (MPA), vigorous (VPA)) assessed using accelerometry | Baseline to 8 weeks for both diets |
| Changes in physical activity levels at 8 weeks between Diet A and Diet B | Change in subjectively reported physical activity levels (sedentary, light (LPA), moderate (MPA), vigorous (VPA)) assessed using the short form International Physical Activity Questionnaire (IPAQ-SF). The short-form International Physical Activity Questionnaire (IPAQ-SF) is a standardised questionnaire consisting of 7 questions that ask about physical activity in the past 7 days. IPAQ-SF will be used to subjectively assess time spent in light, moderate and vigorous physical activity levels, and time spent sitting. The questionnaire takes a few minutes to complete. Higher physical activity values indicate greater physical activity levels, higher time spent sitting indicates greater sedentary behaviour. | Baseline to 8 weeks for both diets |
| Changes in physical activity after 6-months of the behavioural support | (a) Change in objectively reported physical activity levels (sedentary, light (LPA), moderate (MPA), vigorous (VPA)) assessed using accelerometry | First baseline to 6-months follow-up |
| Changes in physical activity levels after 6-months of the behavioural support | Change in subjectively reported physical activity levels (sedentary, light (LPA), moderate (MPA), vigorous (VPA)) assessed using the short form International Physical Activity Questionnaire (IPAQ-SF). The short-form International Physical Activity Questionnaire (IPAQ-SF) is a standardised questionnaire consisting of 7 questions that ask about physical activity in the past 7 days. IPAQ-SF will be used to subjectively assess time spent in light, moderate and vigorous physical activity levels, and time spent sitting. The questionnaire takes a few minutes to complete. Higher physical activity values indicate greater physical activity levels, higher time spent sitting indicates greater sedentary behaviour. | First baseline to 6-months follow-up |
| Changes in handgrip strength at 8 weeks between Diet A and Diet B | Assessed using a hand dynamometer. | Baseline to 8 weeks for both diets |
| Changes in handgrip strength after 6-months of the behavioural support | Assessed using a hand dynamometer. | First baseline to 6-months follow-up |
| Changes in walking distance at 8 weeks between Diet A and Diet B | Assessed using the 6-minute walk test (6MWT) | Baseline to 8 weeks for both diets |
| Changes in changes in walking distance after 6-months of the behavioural support | Assessed using the 6-minute walk test (6MWT) | First baseline to 6-months follow-up |
| Changes in leg strength at 8 weeks between Diet A and Diet B | Assessed using the sit-to-stand (STS) test | Baseline to 8 weeks for both diets |
| Changes in leg strength after 6-months of the behavioural support | Assessed using the sit-to-stand (STS) test | First baseline to 6-months follow-up |
| Changes in quality of life at 8 weeks between Diet A and Diet B | Assessed using EuroQoL 5 dimensions 3 levels (EQ-5D-3L) EQ-5D-3L is a 6-item self-reported questionnaire that consists of a descriptive system to assess the following 5 domains: mobility, self-care, usual activities, pain/discomfort and anxiety/depression using 3 levels (e.g. mobility: I have no problems walking about, I have some problems walking about, or I am confined to bed, higher score indicates worse quality of life) and a visual analogue scale, which records self-rated health on a 0 to 100 scale (100 = best health). | Baseline to 8 weeks for both diets |
| Changes in quality of life after 6-months of the behavioural support | Assessed using EuroQoL 5 dimensions 3 levels (EQ-5D-3L) EQ-5D-3L is a 6-item self-reported questionnaire that consists of a descriptive system to assess the following 5 domains: mobility, self-care, usual activities, pain/discomfort and anxiety/depression using 3 levels (e.g. mobility: I have no problems walking about, I have some problems walking about, or I am confined to bed, higher score indicates worse quality of life) and a visual analogue scale, which records self-rated health on a 0 to 100 scale (100 = best health). | First baseline to 6-months follow-up |
| Changes in weight-related quality of life at 8 weeks between Diet A and Diet B | Assessed using Impact of Weight on Quality of Life-Lite (IWQOL-Lite) Impact of Weight on Quality of Life-Lite (IWQOL-Lite) is a 31-item, self-reported, obesity and overweight-specific measure of health-related quality of life. This tool consists of a total score, scoring on five aspects - physical function, self-esteem, sexual life, public distress, and work. Higher scores indicate a better quality of life. | Baseline to 8 weeks for both diets |
| Changes in weight-related quality of life after 6-months of the behavioural support | Assessed using Impact of Weight on Quality of Life-Lite (IWQOL-Lite) Impact of Weight on Quality of Life-Lite (IWQOL-Lite) is a 31-item, self-reported, obesity and overweight-specific measure of health-related quality of life. This tool consists of a total score, scoring on five aspects - physical function, self-esteem, sexual life, public distress, and work. Higher scores indicate a better quality of life. | First baseline to 6-months follow-up |
| Changes in mental wellbeing at 8 weeks between Diet A and Diet B | Assessed using Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) The Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) is a 14-item, positively worded, validated measure of mental wellbeing, with 5 responses, which are summed to produce a single measure of wellbeing. Scores range from 14 to 70, with higher scores indicating greater positive mental wellbeing. | Baseline to 8 weeks for both diets |
| Changes in mental wellbeing after 6-months of the behavioural support | Assessed using Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) The Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) is a 14-item, positively worded, validated measure of mental wellbeing, with 5 responses, which are summed to produce a single measure of wellbeing. Scores range from 14 to 70, with higher scores indicating greater positive mental wellbeing. | First baseline to 6-months follow-up |
| Changes in depression at 8 weeks between Diet A and Diet B | Assessed using Patient Health Questionnaire-9 (PHQ-9) The Patient Health Questionnaire (PHQ-9) is a 9-item validated measure, which will be used to assess the severity of depression. Each item is rated from 0 to 3, for a total score out of 27. A score of 15-19 indicates moderately severe depression, and 20-27 indicates severe depression. | Baseline to 8 weeks for both diets |
| Changes in depression after 6-months of the behavioural support | Assessed using Patient Health Questionnaire-9 (PHQ-9) The Patient Health Questionnaire (PHQ-9) is a 9-item validated measure, which will be used to assess the severity of depression. Each item is rated from 0 to 3, for a total score out of 27. A score of 15-19 indicates moderately severe depression, and 20-27 indicates severe depression. | First baseline to 6-months follow-up |
| Changes in anxiety at 8 weeks between Diet A and Diet B | Assessed using Generalised Anxiety Disorder Assessment-7 (GAD-7) The Generalised Anxiety Disorder assessment (GAD-7) is a 7-item anxiety scale, which will be used to screen and measure the severity of generalised anxiety disorder. Each item is rated from 0 to 3, for a total score out of 21. A score of 11-15 indicates moderately severe anxiety, and 16-21 of severe anxiety. | Baseline to 8 weeks for both diets |
| Changes in anxiety after 6-months of the behavioural support | Assessed using Generalised Anxiety Disorder Assessment-7 (GAD-7) The Generalised Anxiety Disorder assessment (GAD-7) is a 7-item anxiety scale, which will be used to screen and measure the severity of generalised anxiety disorder. Each item is rated from 0 to 3, for a total score out of 21. A score of 11-15 indicates moderately severe anxiety, and 16-21 of severe anxiety. | First baseline to 6-months follow-up |
| Changes in eating behaviour (psychological impact of living in food-abundant environments) at 8 weeks between Diet A and Diet B | Assessed using Power of Food scale The Power of Food (PoF) scale is a 15-item validated measure, which will be used to assess the psychological impact of living in food-abundant environments. Higher scores indicate greater psychological impact of living in a food-abundant environment | Baseline to 8 weeks for both diets |
| Changes in eating behaviour (psychological impact of living in food-abundant environments), after 6-months of the behavioural support | Assessed using Power of Food scale The Power of Food (PoF) scale is a 15-item validated measure, which will be used to assess the psychological impact of living in food-abundant environments. Higher scores indicate greater psychological impact of living in a food-abundant environment | First baseline to 6-months follow-up |
| Changes in eating behaviour (severity and type of food cravings) at 8 weeks between Diet A and Diet B | Assessed using Control of Eating Questionnaire The Control of Eating Questionnaire (CoEQ) is a 21-item validated measure, which will be used to measure the severity and type of food cravings. Higher scores indicate greater agreement with the statement (severity and type of food cravings) | Baseline to 8 weeks for both diets |
| Changes in eating behaviour (severity and type of food cravings), after 6-months of the behavioural support | Assessed using Control of Eating Questionnaire The Control of Eating Questionnaire (CoEQ) is a 21-item validated measure, which will be used to measure the severity and type of food cravings. Higher scores indicate greater agreement with the statement (severity and type of food cravings) | First baseline to 6-months follow-up |
| (In a subset of participants) Changes in brain functional resting state connectivity at 8 weeks between Diet A and Diet B | Assessed using functional brain magnetic resonance imaging and diffusion weighted imaging. | Baseline to 8 weeks for both diets |
| (In a subset of participants) Changes in brain functional resting state metabolism at 8 weeks between Diet A and Diet B | Metabolite changes assessed using magnetic resonance spectroscopy. | Baseline to 8 weeks for both diets |
| Changes in aspects of behaviour regulation after 6-months of the behavioural support programme | (a) Barriers and facilitators to healthy eating and physical activity, assessed using a capability, opportunity, motivation - behaviour (COM-B) questionnaire Participants will complete one questionnaire investigating the barriers and facilitators to physical activity and healthy eating, based on the COM-B model of behaviour change. The survey contains 257 items; the physical activity component contains 137 items, and the eating component contains 120 items.This survey is expected to take 30 minutes. The survey uses a range of items (Likert scale, yes/no, agree/disagree, true/false) with levels of agreement yes/no indicating barriers or facilitators to behaviour. | First baseline to 6-months follow-up (49 weeks) |
| Barriers and facilitators to eating a healthy, balanced diet | Assessed using a one to one semi-structured telephone/video call interview at 6-months follow-up The aim of the qualitative interviews is to gain an in-depth understanding of the barriers and facilitators to adherence to a minimally processed diet, and to map these onto an intervention development framework. Interviews will follow a simple topic guide designed to explore motivations for participating and experiences of the trial, with a particular focus on barriers and facilitators to adhering to a minimally processed diet. The qualitative process will use Framework Analysis and other methods of thematic analysis designed to explore experiences of a behaviour change trials. | 6-months follow-up |
| Changes in diet after 6-months of the behavioural support programme | (a) Changes in food and nutrient intake, assessed using 24-hour recall (Intake24) 24-hour recalls will be conducted using Intake24, a validated, online, self-reported dietary recall system, based on a multiple-pass 24-hour recall that is suitable for the general population (https://intake24.co.uk). The recall takes on average 12 minutes to complete58. The system is self-completed and will guide the participant through the recall process. Firstly, the user will list all food and drink consumed, followed by probing questions about quantity consumed and further information on food and drink reported. | First baseline to 6-months follow-up |
| Changes in habitual diet after 6-months of the behavioural support programme | (a) Changes in food and nutrient intake, assessed using food frequency questionnaire (FFQ) (European Prospective Investigation of Cancer (EPIC)-Norfolk FFQ) Food frequency questionnaires can be used to determine average food intakes over longer durations of time. Average food intakes will be assessed using the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk FFQ, a validated, semi-quantitative measure of average dietary intake over the past year. The EPIC-Norfolk FFQ is split into two sections, part 1 contains a 130-item food list. Each item contains an individual food, combination of individual foods or a food type. Participants tick the most appropriate frequency of consumption of that food item from nine options (from never or less than once per month, to 6+ per day). Part 2 asks more detailed questions relating to the food items in part 1, including types of fats used in cooking, types of milks consumed and choice of cereals. | First baseline to 6-months follow-up |
| Changes in weekly food shopping expenditure at 6-months follow-up will be compared with the first baseline, based on changes in reported dietary intakes | Assessed using 24-hour recall (Intake24) 24-hour recalls will be conducted using Intake24, a validated, online, self-reported dietary recall system, based on a multiple-pass 24-hour recall that is suitable for the general population (https://intake24.co.uk). The recall takes on average 12 minutes to complete58. The system is self-completed and will guide the participant through the recall process. Firstly, the user will list all food and drink consumed, followed by probing questions about quantity consumed and further information on food and drink reported. | First baseline to 6-months follow-up |
| Derived |
| Dicken SJ, Jassil FC, Brown A, Kalis M, Stanley C, Ranson C, Ruwona T, Qamar S, Buck C, Mallik R, Hamid N, Bird JM, Brown A, Norton B, Gandini Wheeler-Kingshott CAM, Hamer M, van Tulleken C, Hall KD, Fisher A, Makaronidis J, Batterham RL. Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial. Nat Med. 2025 Oct;31(10):3297-3308. doi: 10.1038/s41591-025-03842-0. Epub 2025 Aug 4. |
| 38471681 | Derived | Dicken S, Makaronidis J, van Tulleken C, Jassil FC, Hall K, Brown AC, Gandini Wheeler-Kingshott CAM, Fisher A, Batterham R. UPDATE trial: investigating the effects of ultra-processed versus minimally processed diets following UK dietary guidance on health outcomes: a protocol for an 8-week community-based cross-over randomised controlled trial in people with overweight or obesity, followed by a 6-month behavioural intervention. BMJ Open. 2024 Mar 11;14(3):e079027. doi: 10.1136/bmjopen-2023-079027. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 15, 2026 |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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