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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG071585 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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The effects of pain on cognitive performance have not been thoroughly investigated. Broadly, the purpose of this research is to investigate the effects of acute pain on performance of a variety of cognitive performance measures. The investigators hypothesize that acute pain impairs cognitive performance, particularly cognitive measures of working memory, attention, and processing speed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pain Stimulus | Experimental | Capsaicin combined with heat applied to intact skin |
|
| Distractor Somatosensory Stimulus | Active Comparator | Sensory transcutaneous electrical nerve stimulation (TENS) applied to intact skin |
|
| No Stimulus | No Intervention | Nothing applied to skin |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pain delivery with capsaicin and heat | Procedure | Experimental pain paradigm delivered (capsaicin cream combined with heat) that is short-term and painful but not harmful |
|
| Measure | Description | Time Frame |
|---|---|---|
| Digit Span Forward & Backward Test | number of digits (numbers) that can be repeated back in the same (DS forward) or the reverse (DS backward( order from which they were presented | the change between baseline and delivery (during application of intervention) |
| Trail Making Test A & B | time required to draw a line connecting a series of numbers (TM-A) or a series of alternating letters and numbers (TM-B) | the change between baseline and delivery (during application of intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Conner's Continuous Performance Test (CPT) 3 | response time for letters vs. 'x' stimuli; number of correct inhibited responses | the change between baseline and delivery (during application of intervention) |
| Hopkins Verbal Learning Test- Revised |
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Abbreviations: HR= heart rate, bpm= beats per minute; BP= blood pressure; ADD= attention deficit disorder; ADHD= attention deficit hyperactivity disorder; MoCA= Montreal Cognitive Assessment; GAD-7= Generalized Anxiety Disorder 7 Scale; PHQ-2, PHQ-9= Patient Health Questionnaire-2 and -9.
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susanne M Morton, PhD | University of Delaware | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Delaware | Newark | Delaware | 19713 | United States |
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| ID | Term |
|---|---|
| D059787 | Acute Pain |
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D002211 | Capsaicin |
| D006358 | Hot Temperature |
| ID | Term |
|---|---|
| D053284 | Polyunsaturated Alkamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000475 | Alkenes |
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Application of pain or attentional control or no stimulus cannot be masked from participants, nor from outcomes assessors.
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| distractor delivery with sensory TENS | Procedure | Distractor stimulus delivered (sensory TENS electrical stimulation) that is short-term and attention-demanding but not painful |
|
verbal memory for 3 semantic categories of 4 nouns each; immediate and delayed recall
| the change between baseline and delivery (during application of intervention) |
| Brief Visuospatial Memory Test- Revised | visual memory for 6 shapes and their location on a page; immediate and delayed recall and recognition | the change between baseline and delivery (during application of intervention) |
| Stroop Test | response time and number of errors when stating the name of words printed in a congruent, neutral or incongruent color compared to the meaning of the words | the change between baseline and delivery (during application of intervention) |
| Wisconsin Card Sorting Test | number of trials taken to deduce the new rule when the rules of a card game are changed without warning and without knowing what any of the rules are | the change between baseline and delivery (during application of intervention) |
| Delis Kaplan Executive Functional System (D-KEFS) - Verbal Fluency Section | number of words stated that match a certain category or start with a certain letter in a given time period | the change between baseline and delivery (during application of intervention) |
| NIH Toolbox Picture Sequence | reproduce the correct sequence of pictures | the change between baseline and delivery (during application of intervention) |
| NIH Toolbox Flanker | response time and errors when asked to focus on a single visual stimulus amongst distractors | the change between baseline and delivery (during application of intervention) |
| NIH Toolbox List Sorting | recall and sequencing of different visually and orally presented stimuli | the change between baseline and delivery (during application of intervention) |
| NIH Toolbox Dimension Change Card Sort | errors selecting the correct dimension upon which to select a card, a cue for which is provided | the change between baseline and delivery (during application of intervention) |
| NIH Toolbox Pattern Comparison | errors and time required to determine whether several sets of two pictures are the same or not | the change between baseline and during application of intervention |
| Wechsler 4th ed - Spatial Addition | errors and time required to add or subtract the location of circles on a screen based on a given set of rules | the change between baseline and delivery (during application of intervention) |
| D006839 |
| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D005229 | Fatty Acids, Monounsaturated |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D013696 | Temperature |
| D013816 | Thermodynamics |
| D055585 | Physical Phenomena |
| D014887 | Weather |
| D001272 | Atmosphere |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |