This is a prospective and retrospective study to evaluate the effect of pre-operative therapy on response and survival, and compare the difference in response and survival by pre-operative regimen or by patient's clinicopathological characteristic in early or advanced breast cancer.

Inclusion Criteria:

• Female, Aged ≥18 years
• Histologically confirmed primary breast cancer
• Plan to receive pre-operative therapy
• Adequate organ function

Exclusion Criteria:

• History of neurological or psychological disease, including epilepsy or dementia
• Not suitable to participate in this study judged by investigators

The study population will be selected from the hospital where they are treated