Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for research from patients with known or suspected lung cancer. The information learned from the biospecimens may be used in future treatments. The purpose of this protocol is to create a pleural fluid registry for use in future studies.

Inclusion Criteria:

• Patients who are 18 years or older
• Inpatients and outpatients
• Diagnosed with pleural fluid, are referred for and undergo clinically indicated drainage who have clinical evidence of:
• pulmonary infection (such as fever, leukocytosis, new or worsening infiltrate on chest x-ray, or clinical deterioration) with effusion
• malignancy

Exclusion Criteria:

• A subject will not be eligible for inclusion in this registry if, in the investigator's (or treating clinician's) opinion, the patient has any concurrent medical condition that may preclude their ability to undergo pleural fluid drainage safely.
• Incarcerated individuals

UNC patients

There is no plan to share IPD with other researchers.