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| Name | Class |
|---|---|
| Copenhagen University Hospital at Herlev | OTHER |
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Alcoholic hepatitis is a disease with a high mortality rate with few treatment options improving survival. Recently certain bacterial strains has been correlated to survival in patients with alcoholic hepatitis.
In the BATTLE-trial the investigators will investigate if certain bacteria are correlated to decreased chance of survival in patients with alcoholic hepatitis.
Patients with alcoholic hepatitis who are admitted to Copenhagen University Hospital Hvidovre and Herlev will be invited to participate.
Blood and fecal samples following hospital admission will be collected. Through one-year follow-up correlation of certain bacteria in fecal samples with survival will be investigated.
In particular whether patients with cytolysin producing E. faecalis has a decreased chance of survival compared to patients without this bacteria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hospital admitted patients with alcoholic hepatitis | Inclusion criteria: Age ≥ 18 Bilirubin > 50 micromol/L History of large alcoholic consumption in period prior to hospital admission (in the last six months) No bile-duct obstruction (investigated through US, CT og MRI) Exclusion criteria: Hepatocellulary carcinoma Viral hepatitis Autoimmune hepatitis Portal thrombosis Pregnancy Expected survival for less than one year caused by other diseases (based on decision from project responsible doctors) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival in patients with and without cytolysin producing E. faecalis in fecal samples | Patient alive/not alive - Cytolysin producing E. faecalis in fecal samples from hospital admission (yes/no) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Survival in patients with and without cytolysin producing E. faecalis in fecal samples | Patient alive/not alive - Cytolysin producing E. faecalis in fecal samples from hospital admission (yes/no) | 1 year |
| Survival in patients with and without cytolysin producing E. faecalis in fecal samples |
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Inclusion Criteria:
Exclusion Criteria:
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Hospital admitted patients with alcoholic hepatitis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| frederik cold, MD, PHD | Contact | +4521157167 | frederik.cold@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| frederik cold, MD, PHD | Copenhagen University Hospital, Hvidovre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Copenhagen University Hospital Hvidovre | Recruiting | Hvidovre | 2650 | Denmark |
No plan to make data available to researchers
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| ID | Term |
|---|---|
| D006519 | Hepatitis, Alcoholic |
| ID | Term |
|---|---|
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D008108 | Liver Diseases, Alcoholic |
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Fecal samples collected
Patient alive/not alive - Cytolysin producing E. faecalis in fecal samples from hospital admission (yes/no) |
| 30 days |
| Survival in patients with and without cytolysin producing E. faecalis in fecal samples | Patient alive/not alive - Cytolysin producing E. faecalis in fecal samples from hospital admission (yes/no) | 90 days |
| D020751 |
| Alcohol-Induced Disorders |
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |