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The aim was aimed to investigate if all carbohydrate groups eliminated in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS.
in a randomized cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for three months without wash-out-periods. Gastrointestinal symptoms, Quality of life was measured at baseline and after each intervention diet.
Low FODMAP diets contain 3 major types of carbohydrates to be avoided. The clasical diet is very difficult to maintain over longer periods of time. Therefore, we aimed to investigate if all carbohydrate groups in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS.
Patients diagnosed with IBS according to the Rome III criteria were randomised in a cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for a total of three months without wash-out-periods. Gastrointestinal symptoms were assessed by the Birmingham IBS questionnaire and adequate relief (IBS-AR). Quality of life was measured by the IBS Quality of Life Scale questionnaire (IBS-QOL). All registrations were performed at baseline and after each intervention diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low FODMAP diet | Experimental | Diet low in all kinds of FODMAPS |
|
| Low Fodmap diet but polyols allowed | Placebo Comparator | Diet low in FOS and GOS |
|
| Low Fodmap diet but FOS and GOS allowed | Active Comparator | Diet low in polyols |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low FODMAP DIET = Diet with Low polyol, FOS and GOS | Other | Low Polyol diet |
|
| Measure | Description | Time Frame |
|---|---|---|
| Birmingham IBS questionnaire and adequate relief (IBS-AR). | Score in points (low score means few symptoms) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| IBS Quality of Life Scale questionnaire (IBS-QOL) | Score in points (high score means better life satisfaction) | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens R Andersen, MD, MPA | University of Copenhagen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Copenhagen | Copenhagen | Frederiksberg | 1958 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41278484 | Derived | Jensen LG, Kjaer M, Andersen JR. Modification of the Low FODMAP Diet Is Feasible in the Treatment of Irritable Bowel Syndrome: A Randomised Crossover Study. Gastroenterol Res Pract. 2025 Nov 13;2025:4152978. doi: 10.1155/grp/4152978. eCollection 2025. |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| D000092622 | FODMAP Diet |
| ID | Term |
|---|---|
| D000092724 | Elimination Diets |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
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Cross-over of 3 variations of the low FODMAP diet excluding 1 of the 3 components in every period
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| D004066 | Digestive System Diseases |
| D010829 | Physiological Phenomena |