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The objective of this study is simulate the clinical use of a test material within a 24h window. Efficacy will be simulated as the capacity of the material to reduce or clear the anterior nares bacterial population from opportunistic pathogens (e.g. Staphylococcus Aureus, Escherichia Coli, etc).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saline | Placebo Comparator | this treatment consists of sterile saline that is applied to the nares using a swab |
|
| Povidone-iodine based gel | Active Comparator | this treatment consists of a Povidone-Iodine based gel that is applied to the nares using a swab |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saline applied via swab | Other | sterile saline applied via swab |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Colony Forming Units | up to 24 hours following application |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Innovation and Research Organization | Philadelphia | Pennsylvania | 19107 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39033201 | Derived | Fernandez-Rodriguez D, Cho J, Chisari E, Citardi MJ, Parvizi J. Nasal microbiome and the effect of nasal decolonization with a novel povidone-iodine antiseptic solution: a prospective and randomized clinical trial. Sci Rep. 2024 Jul 20;14(1):16739. doi: 10.1038/s41598-023-46792-8. |
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| ID | Term |
|---|---|
| D058345 | Asymptomatic Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D058070 | Asymptomatic Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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| Povidone-iodine based gel |
| Other |
gel applied via swab |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |