A Comparison of Contact Aspiration Versus Stent Retriever... | NCT05615038

Status Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Contact aspiration first line thrombectomy	Experimental	Patients will have the mechanical thrombectomy by first-line contact aspiration	Procedure: Contact aspiration Thrombectomy
Stent retriever first line thrombectomy	Active Comparator	Patients will have the mechanical thrombectomy by first-line stent retriever	Procedure: Stent retriever thrombectomy

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Contact aspiration Thrombectomy	Procedure	Contant aspiration is an approach that utilizes the advantages of large-bore aspiration catheters that can be easily tracked and introduced into the cerebral circulation to directly remove the thrombus via negative pressure aspiration.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Rate of first pass effect (FPE)	[The definition of FPE: 1) single pass/use of the device; 2)recanalization of the large vessel occlusion to eTICI 2C/3;3) no use of rescue therapy.]	24 hours

Secondary Outcomes

Measure	Description	Time Frame
Rate of complete reperfusion (eTICI 3) after first-line thrombectomy strategy and at the end of endovascular procedure	eTICI： grade 0: no perfusion noted (0% reperfusion) grade 1: reduction in thrombus but without any resultant filling of distal arterial branches grade 2 grade 2a: reperfusion of 1-49% of the territory grade 2b50: reperfusion of 50-66% of the territory grade 2b67: reperfusion of 67-89% of the territory grade 2c: extensive reperfusion of 90-99% of the territory grade 3: complete or full reperfusion (100% reperfusion)

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Clinical Exclusion Criteria:

Baseline mRS≥3 points;
Known or suspected severe basilar artery stenosis (>70%) or chronic occlusion based on history, imaging, or clinical manifestations;
Refractory hypertension that is difficult to be controlled by drugs (defined as persistent systolic blood pressure >185 mmHg or diastolic blood pressure >110 mmHg)
Genetic or acquired hemorrhagic tendency, coagulation factor deficiency or on anticoagulant therapy and International Normalized Ratio (INR) > 3.0;
Laboratory tests: baseline blood glucose <50mg/dl (2.8mmol/L) or >400mg/dl (22.2mmol/L); Baseline platelet count <50×109/L;
Known severe allergy (more severe than skin rash) to contrast agents uncontrolled by medications;
Females who are pregnant, or those of childbearing, potential with positive urine or serum beta Human Chorionic Gonadotropin test;
Other circumstances that the investigator considers inappropriate for participation in the trial or that may pose significant risks to patients (such as inability to understand and/or follow the study procedures and/or follow up due to mental disorders, cognitive or emotional disorders).

Imaging Exclusion Criteria:

CT or MR evidence of acute intracranial hemorrhage (the presence of microbleeds on MRI is allowed);
Midline shift or herniation, mass effect with effacement of the ventricles;
Complete cerebellar infarct on CT or MRI with significant mass effect and compression of the 4-th ventricle;
Complete bilateral thalamic infarction on CT or MRI;
Inability to endovascular treatment due to Excessive tortuosity, variation, or dissection of the artery;
Subjects with occlusions in both intracranial vertebral arteries;
Subjects with occlusions in both anterior and posterior circulation;
Evidence of intracranial tumor (except small meningioma).

Facility	Status	City	State	ZIP	Country	Contacts
The First Affiliated Hospital of Anhui Medical University		Hefei	Anhui		China
Beijing Anzhen Hospital

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
41151802	Derived	Xuan S, Yang M, Sun D, Song L, Gao F, Mo D, Ma N, Pan Y, Liu L, Zhao X, Wang Y, Wang Y, Nogueira R, Miao Z. Contact aspiration versus stent retriever thrombectomy for acute basilar artery occlusion (ANGEL-COAST): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint trial. Stroke Vasc Neurol. 2025 Oct 28:svn-2025-004232. doi: 10.1136/svn-2025-004232. Online ahead of print.