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Metabolic syndrome (MetSyn) is a growing health concern, with up to 25% of the worlds population having the syndrome. MetSyn is a primary risk factor for cardiovascular disease and type II diabetes development, and is independently associated with all-cause mortality, making it an important disease target. The primary treatment for MetSyn is exercise and weight loss, along with medically necessary treatment. Exercise, along with dietary changes such as increased fiber and polyphenol intake can positively impact many of the metabolic abnormalities seen with MetSyn. For example, polyphenols have been shown to decrease lipid concentration and improved glucose clearance as well as decreased oxidative stress and inflammation. Powdered tart cherry capsules, which contain the skin of the fruit, provides polysaccharides (fiber) that would likely act as a substrate for gut bacteria degradation, providing energy substrates and barrier integrity to the colonocytes and increasing the bioavailability of the polyphenols to other cells in the body. However there have been no long-term investigations into the use of powdered tart cherry supplements in MetSyn, therefore we aim to determine if 60 days tart cherry supplementation modify criteria for MetSyn in currently diagnosed individuals including body mass, waist circumference, blood pressure, blood lipid levels and blood glucose control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tart cherry | Experimental | two capsules daily for 60 days |
|
| placebo | Placebo Comparator | two capsules daily for 60 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Powdered tart cherry | Dietary Supplement | 500 mg freeze-dried tart cherry per capsule |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in baseline systolic and diastolic blood pressure | baseline, 60 days post supplmentation | |
| Change in fasting high-density lipoprotein (HDL) cholesterol | baseline, 30 days post supplementation, 60 days post supplmentation | |
| Change in fasting triglyceride levels | baseline, 30 days post supplementation, 60 days post supplmentation | |
| Change in fasting blood glucose level | baseline, 30 days post supplementation, 60 days post supplmentation | |
| Change in waist circumference | baseline, 60 days post supplmentation | |
| Change in body fat distribution | baseline, 60 days post supplmentation | |
| Change in erythrocyte sedimentation rate | baseline, 30 days post supplementation, 60 days post supplmentation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio University Exercise Physiology Lab | Athens | Ohio | 45701 | United States |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Placebo |
| Dietary Supplement |
500 mg colored cornstarch per capsule |
|
| D009750 |
| Nutritional and Metabolic Diseases |