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Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.
The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.
Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.
The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.
This retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in Esenler Gynecology and Pediatrics Hospital Pediatric Clinic between 01 January-30 June 2019.
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| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the effect of measles vaccination status on symptom duration | compare the groups symptom durations (day) who fully, partly or not vaccinated | baseline |
| Evaluate the effect of vitamin A treatment on symptom duration | compare the groups symptom durations (day) who get or not get vitamin A treatment | in the first month after the first symptom observed |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the effect of measles vaccination status on leucocyte count | compare the groups leucocyte count who fully, partly or not vaccinated | baseline |
| Evaluate the effect of vitamin A treatment on leucocyte count |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the effect of measles vaccination status on cost of measles cases | compare the groups costs (Turkish Lira) who fully, partly or not vaccinated | in the first month after the first symptom observed |
| Evaluate the effect of vitamin A treatment on cost of measles cases |
Inclusion Criteria:
Exclusion Criteria:
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Measles case according to with clinical features and attended Pediatric Clinic between 01 January-30 June 2019
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| Name | Affiliation | Role |
|---|---|---|
| Mahmut Caner US, MD | haseki Education and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Esenler Maternity and Child Health Hospital | Istanbul | Esenler | 34230 | Turkey (Türkiye) | ||
| Haseki Training and Research Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32190947 | Background | Lord H, Kok J, Fletcher S, Alexander K. Is it or is it not? Lessons learned from a case of suspected vaccine strain measles. Aust N Z J Public Health. 2020 Apr;44(2):160-162. doi: 10.1111/1753-6405.12969. Epub 2020 Mar 19. | |
| 30636224 | Background | Lo Vecchio A, Krzysztofiak A, Montagnani C, Valentini P, Rossi N, Garazzino S, Raffaldi I, Di Gangi M, Esposito S, Vecchi B, Melzi ML, Lanari M, Zavarise G, Bosis S, Valenzise M, Cazzato S, Sacco M, Govoni MR, Mozzo E, Cambriglia MD, Bruzzese E, Di Camillo C, Pata D, Graziosi A, Sala D, Magurano F, Villani A, Guarino A, Galli L; SITIP Measles Study Group. Complications and risk factors for severe outcome in children with measles. Arch Dis Child. 2020 Sep;105(9):896-899. doi: 10.1136/archdischild-2018-315290. Epub 2019 Jan 12. |
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Availability of data and material: When needed, all data can be shared with the consent of the participants.
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| ID | Term |
|---|---|
| D008457 | Measles |
| ID | Term |
|---|---|
| D018185 | Morbillivirus Infections |
| D018184 | Paramyxoviridae Infections |
| D018701 | Mononegavirales Infections |
| D012327 | RNA Virus Infections |
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compare the groups leucocyte count who get or not get vitamin A treatment
| baseline |
compare the groups costs (Turkish Lira) who get or not get vitamin A treatment |
| in the first month after the first symptom observed |
| Istanbul |
| Turkey (Türkiye) |
| 28933342 | Background | Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult? Euro Surveill. 2017 Sep 14;22(37):30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614. |
| D014777 | Virus Diseases |
| D007239 | Infections |