This study is a non-interventional observational study. On the baseline (Visit 1), we collect demographic data from all participating subjects according to their daily medical conditions, prescribe drugs and collect validity and safety data according to the research plan in Visit 1 and Visit 2. In addition, we collect data by application on subject's self-awareness symptoms and subject's questionnaire for medical outcome short form health survey (SF-36) every day from the baseline for 4 days.

The investigator will enroll subjects according to Inclusion/Exclusion criteria after obtaining Informed Consent Form from each subject. Enrolled subjects will administer Zoledronic Acid 5mg/100mL once on baseline (Visit 1). The demographic data, prescription data, and medical history, etc will be collected based on the approved protocol. Additionally using application, subject's self-awareness symptoms and subject's questionnaire for medical outcome short form health survey (SF-36) every day from the baseline for 4 days will be collected.

Investigator will also collect any occurrence of fracture through electronic medical record until 48 weeks (Visit 2) from baseline visit.

Inclusion Criteria:

1. Male and female adults 19 years of age or older at the time of screening visit
2. A person who is scheduled to administer the research drug according to the medical judgment of the researcher based on the permission
3. A person who can understand the information provided to the person and can voluntarily sign a written consent form

Exclusion Criteria:

1. Those subject to contraindications to administration according to the drug approval requirements for research

   • Patients with hypersensitivity to the components of this drug or other bisphosphonate drugs Hypocalcemia
   • Patients with severe renal impairment whose creatinine clearance rate is less than 35 mL/min (patients must measure serum creatinine and creatinine clearance before receiving the study drug).
   • Patients receiving Zometa for cancer as an indication
   • Pregnant women, women who may be pregnant, and lactating women

2. Patients participating in other clinical trials (However, registration is possible if you have not received investigational drugs or are participating in other non-interventional observational studies.)

3. In addition to the above, patients whom the researcher (physician in charge) determines are not suitable as subjects of this observational study.

The Study population was calculated by using PASS16, Confidence intervals for one mean procedure.

Not yet decided