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| ID | Type | Description | Link |
|---|---|---|---|
| R00AA027830 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
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The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.
Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan.
People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TMS A | Experimental | TMS administered over right frontal eye field at 10 Hz, 110% of MT, 60 x 5 sec trains, 25 sec ITI |
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| TMS B | Active Comparator | TMS administered over right frontal eye field at 1 Hz, 110% of MT, 7 x 225 sec trains, 30 sec ITI |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TMS | Device | TMS will be administered in a pattern that is either excitatory or inhibitory. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in attention switching | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B |
| Change in sociomoral attention switching | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B |
| Change in cue reactivity | MRI Task- analysis of behavioral data | Baseline, immediately following TMS A, immediately following TMS B |
| Measure | Description | Time Frame |
|---|---|---|
| Change in brain activity attention switching | MRI Task- analysis of imaging (fMRI) data | Baseline, immediately following TMS A, immediately following TMS B |
| Change in brain activity during sociomoral attention switching |
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Inclusion Criteria:
1. Age 18 or Older
2A. (Drinker Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion at least 2 times a month AND/OR reports consuming more than 7 [if female]/ 14 [if male] standard drinks per week on average
2B. (Healthy Volunteer Group): Reports consuming 4 [if female]/ 5 [if male] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 [if female]/ 14 [if male] standard drinks per week on average
Exclusion Criteria:
MRI Contraindications
TMS Contraindications
Family history of schizophrenia or presence of psychotic symptoms
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| SCAMPI Lab | Contact | 334-521-2807 | scampi@auburn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Samantha J Fede, PhD | Principal Investigator | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Auburn University | Recruiting | Auburn | Alabama | 36849 | United States |
Data will be shared through the NIAAA Data Archive according to standard NIAAA procedures. This will include deidentified behavioral, self-report, and imaging data.
Participants will have the option to opt out of having their individual data available.
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| D063425 | Binge Drinking |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
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Participants will be randomly assigned to receive each arm in counterbalanced order (AB or BA).
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MRI Task- analysis of imaging (fMRI) data
| Baseline, immediately following TMS A, immediately following TMS B |
| Change in brain activity during cue reactivity | MRI Task- analysis of imaging (fMRI) data | Baseline, immediately following TMS A, immediately following TMS B |
| D064419 |
| Chemically-Induced Disorders |
| D001523 | Mental Disorders |