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Atopic dermatitis (AD) is a chronic inflammatory dermatosis, common in children. It causes pruritus and skin lesions that can have a significant impact on patients' quality of life. AD can be difficult to treat because of its chronicity, demanding local care, corticophobia and the financial cost of non-reimbursed products. Patients are often looking for therapeutic alternatives. Medical hypnosis is a therapeutic alternative via hypnoanalgesia induced by direct suggestions of comfort and skin soothing and via anxiolysis, by working on stress management and self-esteem reinforcement. Four studies are interested in its action in AD and seem to show a reduction in pruritus, skin pain, an improvement in the intensity of atopic dermatitis, sleep, mood and for some a cure of AD. These results are encouraging but limited by the absence of a control group or by the small population included. Therefore, we propose in a first step to evaluate the feasibility of an hypnosis program through a pilot study, designed in the miniature format of a future, larger scale, randomized controlled trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Therapeutic education program | No Intervention | ||
| Therapeutic education program and Hypnosis | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypnosis | Behavioral | The experimental group will receive 2 standardized hypnosis sessions via the "superhero costume" technique performed during this collective therapeutic education program, completed by a reinforcement through the practice of self-hypnosis at home guided by the listening of an audio recording |
| Measure | Description | Time Frame |
|---|---|---|
| Asses the patient recruitment rate | The recruitment rate is the proportion of patients recruited into the pilot study: number of patients included/number of patients to whom the study was proposed. | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assess patient compliance with self-hypnosis practice | Assess patients' adherence to self-hypnosis practice at home, on a self-reported basis, using an adherence log in the experimental arm by:
| At 1 month, 3 months, and 6 months after inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juliette MIQUEL, MD | Contact | +262 262 35 90 00 | juliette.miquel@chu-reunion.fr | |
| Camille ESPAGNON, MD | Contact | camille.espagnon@laposte.net |
| Name | Affiliation | Role |
|---|---|---|
| Juliette MIQUEL, MD | CHU de la Réunion | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de la Réunion | Recruiting | Saint-Denis | 97400 | Reunion |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41857860 | Derived | Thysebaert Z, Espagnon C, Bocquet V, Bruneau L, Miquel J. Applying medical hypnosis in the management of atopic dermatitis in children and young adolescents: study protocol for a pilot cluster randomised controlled trial (Hypno-AD). BMJ Open. 2026 Mar 18;16(3):e110921. doi: 10.1136/bmjopen-2025-110921. |
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| ID | Term |
|---|---|
| D003872 | Dermatitis |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D006990 | Hypnosis |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D011613 | Psychotherapy |
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|
| Patient lost sight of |
Evaluate the rate of patient who has been lost sight of(M1, M3, M6) in both arms, measured by the proportion of patients lost sight of/number of patients included at baseline |
| At 1 month, 3 months, and 6 months after inclusion |
| Patient satisfaction | Assess patient satisfaction with the hypnosis program in the experimental arm using a satisfaction questionnaire | At 1 month, 3 months, and 6 months after inclusion |
| Improvements to the hypnosis program | Describe possible improvements to the hypnosis program in the experimental arm at M6 through focus group interviews with a group of volunteers aged 8-11 and a group of volunteers aged 12-17. | At 6 months after inclusion |
| Effectiveness | Evaluate the effectiveness of a hypnosis program (exploratory)
| At 1 month, 3 months, and 6 months after inclusion |
| Parents' overall impression | Assess parents' overall impression of their child's AD progress with the hypnosis program, via a questionnaire | At 1 month, 3 months, and 6 months after enrollment |
| D004191 |
| Behavioral Disciplines and Activities |