• Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Out of Hospital Cardiac Arrest

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ClinicalTrials.gov ID

NCT05606809

Lead Sponsor

AfterROSCOTHER

Overall Status

Recruiting

Study Type

Observational

Enrollment

4,500Estimated

Last Update Posted

Oct 3, 2025Actual

Start Date

Nov 2, 2022Actual

Primary Completion Date

Sep 30, 2027Estimated

Completion Date

Dec 31, 2027Estimated

Official Title

Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest

Brief Summary

Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.

• Cardiac Arrest

• Calculation of early prognosis score

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• all adult patients, major, admitted to intensive care after cardiac arrest (after both in and out-of hospital cardiac arrest),
• comatose (defined by Glasgow score ≤ 8) on admission,

Exclusion Criteria:

• cardiac arrest occurring intra-hospital,
• minor patient,
• major patient under guardianship,
• protected persons,
• prior inclusion in the study

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

AfterROSCOTHER

alain.cariou@aphp.fr