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The purpose of this study is to evaluate how variations in oxygen demands may change heart electrical activity in individuals with and without oxygen dependence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Control Group | Active Comparator | Individuals without lung disease will receive oxygen for a period of four hours |
|
| Nocturnal hypoxemia group | Active Comparator | Individuals with lung disease will receive oxygen for a period of four hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nocturnal Oxygen | Other | Nocturnal oxygen will be increased hourly for a period of four hours up to 4 liters per minute (LPM). If the oxygen saturation (SpO2) falls below 70% the oxygen rate will be increased until patients achieve the threshold of 70% and then will proceed with titrations of 1 liter per minute LPM per hour. |
| Measure | Description | Time Frame |
|---|---|---|
| QT Variability Index | Measured from electrocardiogram (ECG) | Up to 10 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Normalized variance of the heart rate (HRVN) | Measured from ECG | Up to 10 hours |
| QT-RR interval | Measured from ECG | Up to 10 hours |
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Healthy Participants
Inclusion Criteria:
• Ability to provide consent
Exclusion Criteria:
Nocturnal Hypoxemia
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Trishul Siddharthan, MD | Contact | 305-243-6388 | tsiddhar@miami.edu |
| Name | Affiliation | Role |
|---|---|---|
| Trishul Siddharthan, MD | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami | Miami | Florida | 33136 | United States |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |