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Blood samples for hemolytic anemia in patients treated with one or more of the antibiotics including piperacillin, amoxicillin, cefazolin, cefuroxime, ceftriaxone, cefoxitin sodium, and vancomycin were screened for the production of drug antibodies.
The widespread use of antibiotics and anti-tumor drugs in clinical practice leads to poor efficacy or even toxic side effects and other adverse events, which are often related to the immune response caused by the cells adsorption or binding because of the long-term use of drugs to cause the generation of antibodies or drug decomposition.The immune hemolytic anemia caused by antibiotics is more common.In this study, the remaining blood samples of patients who developed hemolytic anemia using one or more antibiotics including piperacillin, amoxicillin, cefazolin, cefuroxime, ceftriaxone, cefoxitin sodium and vancomycin were preliminarily screened to determine which drugs caused hemolytic anemia.The types of diseases and antibiotics used in patients with drug-induced hemolytic anemia were also analyzed.The positive rate of drug antibody production was calculated and the difference of drug antibody production mechanism was analyzed.The blood samples of the positive patients and some negative patients were collected and preserved to prepare for the follow-up study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Piperacillin group | Blood samples for hemolytic anemia in patients treated with piperacillin were screened for the production of drug antibodies. | ||
| Amoxicillin group | Blood samples for hemolytic anemia in patients treated with amoxicillin were screened for the production of drug antibodies. | ||
| Cefazolin group | Blood samples for hemolytic anemia in patients treated with cefazolin were screened for the production of drug antibodies. | ||
| Cefuroxime group | Blood samples for hemolytic anemia in patients treated with cefuroxime were screened for the production of drug antibodies. | ||
| Ceftriaxone group | Blood samples for hemolytic anemia in patients treated with ceftriaxone were screened for the production of drug antibodies. | ||
| Cefoxitin sodium group | Blood samples for hemolytic anemia in patients treated with cefoxitin sodium were screened for the production of drug antibodies. | ||
| Vancomycin group |
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| Measure | Description | Time Frame |
|---|---|---|
| To compare the positive rate of drug antibody between different drugs. | The drug-induced hemolytic anemia test kit (microcolumn gel method) was used to determine whether drug antibodies were produced in the participates. | through study completion, an average of 3 years. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with one or more of the antibiotics including piperacillin, amoxicillin, cefazolin, cefuroxime, ceftriaxone, cefoxitin sodium, and vancomycin.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huayou Zhou, Doctor | Contact | 020-61641848 | zohoyo@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanfang hospital of southern medical university | Recruiting | Guangzhou | Gaungdong | China |
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Blood samples for hemolytic anemia in patients treated with vancomycin were screened for the production of drug antibodies. |