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Adenocarcinoma of the anus is rare. It concerns less than 10% of anal cancers and its incidence is less than 0.2/100 000 inhabitants. Its management is not consensual and is most often derived by analogy with that of adenocarcinoma of the lower rectum. This is due to the rarity but also to the diversity of anatomical (anal margin, anal canal, lower rectum), etiological (primary glandular tumors or secondary to anal fistula, primary distant tumor and/or Crohn's disease) and histological forms (mucinous, intestinal, glandular adenocarcinomas and primary or secondary Paget's disease). Most of the literature consists of small case series and simple clinical cases in which the prognosis of these subforms has not been studied.
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| Measure | Description | Time Frame |
|---|---|---|
| Risk of mortality at 1 year, estimated using a survival curve | This outcome corresponds to the 1 year mortality rates after diagnosis of adenocarcinoma of the anus. | Year1 |
| Risk of mortality at 5 years, estimated using a survival curve | This outcome corresponds to the 5 year mortality rates after diagnosis of adenocarcinoma of the anus. | Year5 |
| Measure | Description | Time Frame |
|---|---|---|
| Describe the various anatomical, etiological and histological forms | This outcome corresponds to the classification of anatomical (anal margin, anal canal, lower rectum), etiological (primary glandular tumors or secondary to anal fistula, primary distant tumor and/or Crohn's disease) and histological (mucinous, intestinal, glandular adenocarcinoma and primary or secondary Paget's disease) forms. | Year5 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with a diagnosis of adenocarcinoma of the anus between 01/01/2006 and 30/06/2022 in participating centers
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| Name | Affiliation | Role |
|---|---|---|
| Vincent De PARADES, MD | Fondation Hôpital Saint-Joseph | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Groupe Hospitalier Paris Saint-Joseph | Paris | 75014 | France | |||
| Centre hospitalo-universitaire de Cochin-Port Royal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23809885 | Background | Anwar S, Welbourn H, Hill J, Sebag-Montefiore D. Adenocarcinoma of the anal canal - a systematic review. Colorectal Dis. 2013 Dec;15(12):1481-8. doi: 10.1111/codi.12325. | |
| 34990422 | Background | Lukovic J, Kim JJ, Liu ZA, Cummings BJ, Brierley JD, Wong RKS, Ringash JG, Dawson LA, Barry A, Krzyzanowska MK, Chen EX, Hedley DW, Quereshy FA, Swallow CJ, Gryfe RN, Kennedy ED, Easson AM, Hosni A. Anal Adenocarcinoma: A Rare Entity in Need of Multidisciplinary Management. Dis Colon Rectum. 2022 Feb 1;65(2):189-197. doi: 10.1097/DCR.0000000000002281. |
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| Adaptaion of the therapeutic management according to the clinical and histological form | This outcome corresponds to the Proposed treatments (local excision, abdominoperineal amputation, neoadjuvant treatment, adjuvant treatment, etc.) according to the clinical and histological form. | Year5 |
| Describe their therapeutic management | This outcome corresponds to the Proposed treatments (local excision, abdominal-perineal amputation, neoadjuvant treatment, adjuvant treatment, etc.). | Year5 |
| Compare prognosis by clinical and histological form | This outcome corresponds to the Mortality rate by clinical and histological form. | Year5 |
| Search for prognostic factors of severity in all forms | This outcome corresponds to the Prognostic factors of severity for all forms. | Year5 |
| Paris |
| France |
| 31361759 | Background | Wang Q, Fu J, Chen X, Cai C, Ruan H, Du J. What factors are associated with the poor prognosis of anal adenocarcinoma compared with low-lying rectal adenocarcinoma based on a population analysis: A propensity score matching study. PLoS One. 2019 Jul 30;14(7):e0219937. doi: 10.1371/journal.pone.0219937. eCollection 2019. |
| 33394780 | Background | Yasuhara M, Beppu N, Uchino M, Ikeuchi H, Matsuda I, Hirota S, Ikeda M, Tomita N. Adverse Oncologic Outcomes of Adenocarcinoma of the Anal Canal in Patients With Crohn's Disease. Dis Colon Rectum. 2021 Apr 1;64(4):409-419. doi: 10.1097/DCR.0000000000001874. |
| 31567917 | Background | Lee GC, Kunitake H, Stafford C, Bordeianou LG, Francone TD, Ricciardi R. High Risk of Proximal and Local Neoplasms in 2206 Patients With Anogenital Extramammary Paget's Disease. Dis Colon Rectum. 2019 Nov;62(11):1283-1293. doi: 10.1097/DCR.0000000000001487. |