Rheumatoid arthritis patients being seen at one of the participating clinical sites in a U.S. network of community rheumatology practices who are starting treatment on adalimumab or upadacitinib will be enrolled into a 24-week study combining clinical data from physicians, self-reported patient outcomes from the ArthritisPower registry app, and activity and sleep data from a Fitbit wearable device.

The primary objective of this study is:

• Evaluate longitudinal associations between biometric sensor data (activity and sleep measures), physician-derived data (including clinical disease activity index (CDAI), Rheumatoid Factor (RF) lab results and other relevant biomarkers, current medications and disease duration), and patient-reported outcomes (PROs) (including PROMIS pain interference, physical function, fatigue, sleep disturbance, satisfaction with participation in discretionary social activities, and anxiety).

The secondary objectives of this study are as follows:

• Explore the reliability and predictive validity of biometric sensor data to classify changes in RA disease activity and associated symptoms, including PROs.
• To assess adherence and predictors of adherence with use of biometric sensor
• Assess/track changes in upadacitinib and adalimumab patients using combined physician, PRO and biosensor data.

Inclusion Criteria:

• Age 19 and above who are adults (i.e., the age of majority where they reside)
• Diagnosis of RA by a physician (as indicated by survey screening questions)
• Currently being seen by a U.S. rheumatologist
• Starting on the day of enrollment (with no prior use ever) or soon-to-initiate (i.e. in the next 28 days) upadacitinib or adalimumab for RA
• Ability to walk without the use of assistive devices;
• Have access to a computer or smartphone to take health assessments and a survey;
• Already own a smartphone (iPhone or Android); iPhone 4S and later or Android 4.3 and later
• Are willing to join the ArthritisPower patient registry;
• Are willing to download the ArthritisPower app;
• Are willing to contribute daily and weekly ePROs for at least at 89 days, and health activity tracker data for at least 84 days (lead-in period minimum of 5 days plus main study period 84 days). Some participants may contribute data more than 89 days if there was a lag in receiving their medication and hence later medication start date;
• Are willing to wear the smartwatch while sleeping;
• Are willing to complete the 7-day run-in requirements (i.e. completing daily PRO assessments for at least 5 of 7 days);
• Have started their medication within 30 days of enrolling in the study (i.e. enrolling in ArthritisPower)
• Will not be out of internet access (wifi and/or mobile data) for 4 or more consecutive days during the study; and
• Willing to be contacted by e-mail/text message and/or phone by the study coordinator if participants fail to adhere to the study Protocol or for any study related assistance as required.
• Clinician must collect a CDAI (including the raw scores for the four components - patient global, physician global and tender and swollen joint count) on day of enrollment.
• CDAI must be >10
• Must have rheumatoid and CCP antibody lab results available, or collect those labs (as part of standard of care during the enrollment visit) if not available

The investigators will recruit patients from non-academic clinical settings and the American Arthritis and Rheumatology Associates (AARA) physician network, Bendcare. All patients seen and treated by Bendcare AARA clinicians may participate in this study should they fit the eligibility criteria. Physicians at these sites will identify patients for their coordinators to enroll. All participants must be or must become ArthritisPower members in order to be eligible for this study consistent with Investigator previously approved studies.