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The purpose of this study is to map the acute, short-term cortical evoked responses to thalamic electrical stimulation in persons with intractable epilepsy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RNS/DBS activation | Device | This will be performed to study the EEG responses to DBS/RNS stimulation electrical pulses. The stimulation frequencies will be sequentially increased and each stimulation will last for 2 minutes.There will be a 1-2 minute wash out period after each trial. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in amplitude of evoked potentials metrics as assessed by the scalp EEG | Baseline, Intra intervention (about 20 minutes after baseline) | |
| Change in amplitude of evoked potentials metrics as assessed by the scalp EEG | Baseline, post intervention (about 2 hours after baseline ) | |
| Change in latencies of evoked potentials and phase synchronization metrics recorded as assessed by the scalp EEG | Baseline, Intra intervention (about 20 minutes after baseline) | |
| Change in latencies of evoked potentials and phase synchronization metrics recorded as assessed by the scalp EEG | Baseline, post intervention (about 2 hours after baseline ) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in reaction time to visual stimuli measured as vigilance score assessed by the Psychomotor Vigilance test (PVT) | This is a computerized testing that will record errors in being unable to tap a switch/button | Baseline, Intra intervention (about 20 minutes after baseline) |
| Change in reaction time to visual stimuli measured as vigilance score assessed by the Psychomotor Vigilance test (PVT) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sandipan Pati, MD | Contact | 713-500-7925 | Sandipan.Pati@uth.tmc.edu | |
| Jaison Hampson | Contact | 713-500-7754 | Jaison.S.Hampson@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sandipan Pati, MD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Recruiting | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D000069279 | Drug Resistant Epilepsy |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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|
This is a computerized testing that will record errors in being unable to tap a switch/button |
| Baseline, post intervention (about 2 hours after baseline) |