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Patients with successful left bundle branch pacing in our center were included in this study from April 2018 to December 2019. Baseline data was collected, and pacing parameters, ECG and echocardiographic results were analyzed during 3 years follow-up. According to whether or not a potential was recorded and the specific potential characteristics at implantation, the patients were divided into 3 groups: left bundle branch potential group; Purkinje potential group; and no-potential group. During the 3 years follow-up, the investigators collected the ECG、UCG and pacemaker parameters to analyze.
A total of 136 patients with a high percentage of ventricular pacing and successful left bundle branch pacing were included in this study from April 2018 to December 2019. Baseline data was collected, and pacing parameters, ECG and echocardiographic results were analyzed during 3 years follow-up. According to whether or not a potential was recorded and the specific potential characteristics at implantation, the patients were divided into 3 groups: left bundle branch potential group (L group) 31.6%; Purkinje potential group (P group) 10.3%; and no-potential group (N group) 58.1%. During the 3 years follow-up, the investigators collected the ECG、UCG and pacemaker parameters to analyze.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| left bundle branch potential group | the left bundle branch potential was recorded at implantation |
| |
| Purkinje potential group | the purkinje potential was recorded at implantation |
| |
| no-potential group | no potential was recorded at implantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac pacemaker and Select Secure lead | Device | model 3830, 69cm, Medtronic, Inc., Minneapolis, MN, USA |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in left atrium diameter at 3 years | Echocardiography is measured by a professional using an ultrasound machine, record the following results: left atrium diameter (ms) | Baseline and 3 years |
| Change from Baseline in left ventricular end diastolic diameter at 3 years | Left ventricular end diastolic diameter (ms) | Baseline and 3 years |
| Change from Baseline in left ventricular ejection fraction at 3 years | Left ventricular ejection fraction (%) | Baseline and 3 years |
| Change from Baseline in pulmonary artery systolic pressure at 3 years | Pulmonary artery systolic pressure (mmHg) | Baseline and 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in threshold at 3 years | Threshold was measured with a pace-sensing analyser: threshold (V) at 0.5ms | Baseline and 3 years |
| Change from Baseline in impedance at 3 years | Impedance was measured with a pace-sensing analyser: impedance(Ω) |
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Inclusion Criteria:
Exclusion Criteria:
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From April 2018 to Dec 2019, consecutive patients who were predicted to require a high percentage of ventricular pacing in our center were enrolled in this study. Main indications for the enrolment of patients are atrioventricular block and heart failure (HF) combined with complete left bundle branch block (LBBB). All patients were accorded with indications for pacing therapy of 2013 European Society of Cardiology guidelines on cardiac pacing. The study conforms to the guiding principles of the Declaration of Helsinki and was approved by Ethics Committee of the Linyi People's Hospital. All patients signed the informed consent.
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| Name | Affiliation | Role |
|---|---|---|
| Fingming Li | Linyi People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Linyi People's Hospital | Linyi | Shandong | 276000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31233818 | Background | Huang W, Chen X, Su L, Wu S, Xia X, Vijayaraman P. A beginner's guide to permanent left bundle branch pacing. Heart Rhythm. 2019 Dec;16(12):1791-1796. doi: 10.1016/j.hrthm.2019.06.016. Epub 2019 Jun 22. No abstract available. | |
| 29173611 | Background | Huang W, Su L, Wu S, Xu L, Xiao F, Zhou X, Ellenbogen KA. A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block. Can J Cardiol. 2017 Dec;33(12):1736.e1-1736.e3. doi: 10.1016/j.cjca.2017.09.013. Epub 2017 Sep 22. |
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all collected IPD would be shared after publishing
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| ID | Term |
|---|---|
| D054537 | Atrioventricular Block |
| ID | Term |
|---|---|
| D006327 | Heart Block |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D010138 | Pacemaker, Artificial |
| ID | Term |
|---|---|
| D004566 | Electrodes |
| D055615 | Electrical Equipment and Supplies |
| D004864 | Equipment and Supplies |
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| Baseline and 3 years |
| 33426907 | Background | Su L, Wang S, Wu S, Xu L, Huang Z, Chen X, Zheng R, Jiang L, Ellenbogen KA, Whinnett ZI, Huang W. Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study. Circ Arrhythm Electrophysiol. 2021 Feb;14(2):e009261. doi: 10.1161/CIRCEP.120.009261. Epub 2021 Jan 9. |
| 31322651 | Background | Hou X, Qian Z, Wang Y, Qiu Y, Chen X, Jiang H, Jiang Z, Wu H, Zhao Z, Zhou W, Zou J. Feasibility and cardiac synchrony of permanent left bundle branch pacing through the interventricular septum. Europace. 2019 Nov 1;21(11):1694-1702. doi: 10.1093/europace/euz188. |
| 32623624 | Background | Ponnusamy SS, Muthu G, Kumar M, Bopanna D, Anand V, Kumar S. Mid-term feasibility, safety and outcomes of left bundle branch pacing-single center experience. J Interv Card Electrophysiol. 2021 Mar;60(2):337-346. doi: 10.1007/s10840-020-00807-w. Epub 2020 Jul 4. |
| D000075224 |
| Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |