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Povidone iodine (PI) solution is an antimicrobial solution that can be used at hip and knee arthroplasty cases. It contains iodine that may be absorbed by the body. This study aims to investigate any absorption caused by PI solution.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Povidone Iodine Solution | Active Comparator | The group whom PI solution will be used at surgery |
|
| Saline Solution | Placebo Comparator | The group whom only saline solution will be used at surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PI solution | Procedure | 3,000 cc of <2% concentrated povidone iodine solution will be used as irrigation solution at primary hip/knee arthroplasty. The PI solution was left in the joint for 3 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Urine iodine level | Urine iodine concentration | postoperative first day |
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid hormone | Blood thyroid hormone levels including: TSH, T3 and T4 | postoperative 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hakan Kocaoglu, MD | Contact | 00903125082321 | kocaoglu@ankara.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| Hakan Kocaoglu, MD | Ankara University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara University Faculty of Medicine | Recruiting | Ankara | 06100 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39380015 | Derived | Ertan MB, Basarir K, Kocaoglu H, Aydugan MY, Gungor E. Systemic iodine levels increase with povidone-iodine irrigation, but does this affect thyroid functions? A case-control study. J Orthop Surg Res. 2024 Oct 8;19(1):636. doi: 10.1186/s13018-024-04877-8. |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D006980 | Hyperthyroidism |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| Saline Solution | Procedure | 3,000 cc of 0.9% saline solution will be used as irrigation solution at primary hip/knee arthroplasty. The saline solution was left in the joint for 3 |
|
| D013959 |
| Thyroid Diseases |
| D004700 | Endocrine System Diseases |