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The MISTIK project aims at clinically validating the technique of oral anticancer drugs determination by volumetric absorptive micro-sampling and at comparing the results to measurements performed on venous samples.
The International recommendations for the validation of DBS-based methods will be applied (Capiau et al, TDM, 2019) by including 40 patients per molecule of interest. Nine drugs will be monitored : axitinib, olaparib, regorafénib, cabozantinib, niraparib, talazoparib, palbociclib, abemaciclib, tucatinib.
Two samples will be collected from each patient, one by venous sampling and the second at the same time (approximately) using a capillary blood sample derived from a finger prick.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of drug concentrations | Other | Measurement of anti-cancer drug concentrations using volumetric absorptive micro-sampling (VAMS) and venous blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of venous blood vs VAMS concentrations | Comparison of drug concentrations measured from the venous blood samples with concentrations measured from VAMS | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with one of the 9 drugs concerned by the study : axitinib, olaparib, regorafénib, cabozantinib, niraparib, talazoparib, palbociclib, abemaciclib, tucatinib
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| Name | Affiliation | Role |
|---|---|---|
| VERDIER Marie-Clemence | Rennes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Eugène Marquis Unicancer | Rennes | 35000 | France | |||
| Rennes University Hospital |
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| Rennes |
| 35000 |
| France |
| Institut de cancérologie Strasbourg Europe | Strasbourg | 67033 | France |