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About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome. It will inevitably affect the patient's postoperative recovery. A number of studies have shown that dexmedetomidine, as an auxiliary sedative, has the effects of inhibiting stress response, antiarrhythmia and cardiac protection.Dexmedetomidine has been widely used in anesthesia in cardiac surgery. However, at present, few clinical studies pay attention to its mechanism. In this study, dexmedetomidine will be used in cardiac surgery with cardiopulmonary bypass to explore the mechanism of cardiac ischemia-reperfusion injury and the protective effect of dexmedetomidine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group D | Experimental | The participant will be infused with dexmedetomidine during anesthesia to protect the myocardium. |
|
| Group R | Placebo Comparator | The participant will use saline of the same volume as dexmedetomidine as a placebo during anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dexmedetomidine | Drug | The participant will pump dexmedetomidine at the rate of 1μg/(Kg·h) for 10 minutes at the beginning of anesthesia induction, and then maintain the pump at a rate of 0.5μg/(Kg·h) during the operation. |
| Measure | Description | Time Frame |
|---|---|---|
| troponin T level | the level of troponin in the participant's serum | before operation |
| troponin T level | the level of troponin in the participant's serum | the end of operation |
| troponin T level | the level of troponin in the participant's serum | when the participant returned to the ward after the operation |
| troponin T level | the level of troponin in the participant's serum | 24 hours after operation |
| troponin T level | the level of troponin in the participant's serum | 72 hours after operation |
| Measure | Description | Time Frame |
|---|---|---|
| AQP4、iNOS andTNF-α level | the level of AQP4、iNOS andTNF-α in the participant's serum | before operation |
| AQP4、iNOS andTNF-α level | the level of AQP4、iNOS andTNF-α in the participant's serum |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yibin Qin | Affiliated Hospital of Nantong University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital Nantong University | Nantong | Jiangsu | 226000 | China |
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| Placebo | Drug | The participant will pump saline without dexmedetomidine at the same speed as group D. |
|
| when blocking the ascending aorta |
| AQP4、iNOS andTNF-α level | the level of AQP4、iNOS andTNF-α in the participant's serum | when developing the ascending aorta |
| AQP4、iNOS andTNF-α level | the level of AQP4、iNOS andTNF-α in the participant's serum | when cardiopulmonary bypass is stopped |
| AQP4、iNOS andTNF-α level | the level of AQP4、iNOS andTNF-α in the participant's serum | the end of the operation |
| ID | Term |
|---|---|
| D015427 | Reperfusion Injury |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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