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Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break
In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Group | Patients diagnosed with psychotic disorder. |
| |
| Control Group | Healthy Controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DAPAR Tests (IQ equivalent test) | Diagnostic Test | This study will compare DAPAR scores before and after the onset of the psychotic illness. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in DAPAR (An Israeli cognitive test) scores | Cognitive changes in both groups (lowest 10 - highest 90) | 1 day (During recruitment visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Psychotic Symptoms | PANSS-6 (Positive and Negative Syndrome Scale - Abbrevieted) scores (lowest 0- highest 36) | 1 day (During recruitment visit) |
| Social Functioning | PSP (Personal and Social Performance Scale) Scores (lowest 0- highest 100) |
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Inclusion Criteria - Study Group:
Inclusion Criteria - Control group:
Exclusion Criteria - Both groups:
Exclusion Criteria - Control group:
- Participants who have a first-degree relative who suffers from a psychotic disorder.
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The investigators will recruit patients treated in the psychiatric unit at the Sheba Medical Center and in other medical institutions throughout the country. Additionally, subjects will be recruited through internet advertisement of the study. All subjects will give informed consent.
Control group will be recruited by matching for Age, Sex and socioeconomic status. recruitment will be preforemd by advertisement.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Noaz Cohen, MA | Contact | 972-3-5303325 | noaz.cohen@sheba.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Mark Weiser, MD | Sheba Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheba Medical Center | Recruiting | Ramat Gan | 52621 | Israel |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| D060825 | Cognitive Dysfunction |
| D012559 | Schizophrenia |
| D019964 | Mood Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| 1 day (During recruitment visit) |
| Cognitive Functioning | WAIS-III (Wechsler Adult Intelligence Scale) (4 specific sub-tests) | 1 day (During recruitment visit) |
| Coping strategies | COPE (Assessing Coping Strategies) scores (lowest 0 - highest 90) | 1 day (During recruitment visit) |