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The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:
Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?
Does red light therapy improve forearm muscle endurance compared to a sham light exposure?
Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beet-root juice plus red-light therapy | Experimental |
| |
| Beet-root juice plus sham light therapy | Sham Comparator |
| |
| Placebo plus red-light therapy | Placebo Comparator |
| |
| Placebo plus sham light therapy | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beet-root juice | Dietary Supplement | Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing. |
| Measure | Description | Time Frame |
|---|---|---|
| Total forearm work performed | Work is the product of the number of times the forearm is activated multiplied by the amount of force produced by the forearm in kilograms. | During the forearm exercise fatigue protocol lasting up to 45 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Forearm endurance | The duration of time the participant takes to complete the forearm fatigue protocol | During the forearm exercise fatigue protocol lasting up to 45 minutes |
| Intermuscular coordination |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Andrew D Wells, Ph.D. | Contact | (336) 758-5837 | 2156 | wellsa@wfu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Andrew D Wells, Ph.D. | Wake Forest University, Reynolda Campus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wake Forest Univesity | Recruiting | Winston-Salem | North Carolina | 27106 | United States |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 27, 2026 | Jun 23, 2026 | 3 | ||
| Jul 1, 2026 |
| ID | Term |
|---|---|
| D010342 | Patient Acceptance of Health Care |
| ID | Term |
|---|---|
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| red-light therapy | Radiation | Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes. |
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| Placebo | Dietary Supplement | Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing. |
|
| sham light | Radiation | Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes. |
|
Surface electromyography measurements of muscle activity
| During the forearm exercise fatigue protocol lasting up to 45 minutes |