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Reality-monitoring is a crucial cognitive process in daily life to remember the source of an information. Deficits of reality-monitoring have been shown into the continuum of schizophrenia, suggesting a preexisting alteration in population at-risk for psychosis that will be exacerbated during psychotic transition. It is admitted that stress plays a crucial role in the psychotic transition and can alter cognitive performances. However, less is known about the effects of stress on reality-monitoring, even though this process appears to be central in psychotic disorders.
The aim of this project is to investigate the effect of stress on reality-monitoring, both on behavioral and neurophysiological aspects
Forty healthy subjects will be included in the study. Participants will be subject to a standardized stress protocol, half of them receiving an active stress and the other half receiving a placebo. All participants will also complete a reality-monitoring task, electrophysiological (EEG) recordings as well as socio-demographic and psychometric evaluations
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active stress group | Experimental | 20 healthy subjects will be subject to the active condition of a standardized stress protocol |
|
| placebo stress group | Placebo Comparator | 20 healthy subjects will be subject to the placebo condition of a standardized stress protocol. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute Maastricht Stress Test (MAST), active condition. | Procedure | The MAST is a standardized stress protocol combining a 5 min preparation phase and 10 min acute stress phase. The last phase is composed by an alternation of physical and psychosocial stressors. In the active condition, participants have to switch between immersion of the hand into cold water and complex mental arithmetic operations. |
| Measure | Description | Time Frame |
|---|---|---|
| Reality-monitoring performances | scores obtained at the reality-monitoring task (accuracy, range 0-100%) | within 1 hour after the stress procedure |
| Measure | Description | Time Frame |
|---|---|---|
| electroencephalogram (EEG) activity | EEG activity recorded at rest (spectral power) and during reality-monitoring task | 1time within 1 hour after the stress procedure |
| Working memory | scores at the n-back task (expressed as % of good responses) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| SARTLET Lydie | Contact | 0437915531 | +33 | lydie.sartelet@ch-le-vinatier.fr |
| Mondino Marine, PhD | Contact | 0437915565 | +33 | marine.mondino@ch-le-vinatier.fr |
| Name | Affiliation | Role |
|---|---|---|
| Mondino Marine, PhD | hospital le vinatier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier le Vinatier | Recruiting | Bron | 69678 | France |
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Randomized, controlled, single-blind study including 40 healthy subjects who will be randomly divided into 2 groups.
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Participants will not be informed about the nature (active or placebo) of the stress test they will perform.
|
| Acute Maastricht Stress Test (MAST), placebo condition | Procedure | The MAST is a standardized stress protocol combining a 5 min preparation phase and 10 min acute stress phase. The last phase is composed by an alternation of physical and psychosocial stressors. In the placebo condition, participants have to switch between immersion of the hand into tempered water and simple mental arithmetic counts. |
|
| 1 time within 1 hour after the stress procedure |
| Basic auditory performances | scores at the Tone Matching Task (expressed as % of good responses) | 1 time within 1 hour after the stress procedure |
| Salivary cortisol | Salivary cortisol (in µg/L) | throughout and within 1 hour after the stress procedure |
| Blood pressure | blood pressure (both systolic and diastolic, in mmHg) | throughout and within 1 hour after the stress procedure |
| Heart rate | Heart rate (in beats per minute) | throughout and within 1 hour after the stress procedure |
| expression rate of genes involved in the regulation of the glucocorticoid receptor signaling pathway | The expression rate of genes of the glucocorticoid receptor signaling pathway (NR3C1, FKBP4, HSP90, HSP70, FKBP5, BAG1, PTGES3) | 1 time before and 1 time 1 hour after the stress procedure |
| Subjective stress | Subjective stress assessed with the STAI-YA (scores between 20 and 80) | 1 time before and 1 time 1 hour after the stress procedure |
| Psychometric characteristics that may influence stress response (1) | Scores at the 16-item Prodromal Questionnaire (PQ-16), ranging between 0 and 16 (higher scores indicate higher psychotic risks). | Basline, before the stress procedure |
| Psychometric characteristics that may influence stress response (2) | Scores at the Childhood Trauma Questionnaire (CTQ), between 28 and 140 (higher scores indicate higher trauma exposure) | Basline, before the stress procedure |
| Psychometric characteristics that may influence stress response (3) | State Trait Anxiety Inventory (form B) scores between 40 and 160 20 and 80 (STAI-YB) between 20 and 80 (higher scores indicate higher state anxiety) | Basline, before the stress procedure |
| Psychometric characteristics that may influence stress response (4) | Scores at the Schizotypal Personality Questionnaire (SPQ), between 0 and 74 (higher scores indicate higher schizotypal traits) | Basline, before the stress procedure |
| Psychometric characteristics that may influence stress response (5) | Scores at the Launay-Slade Hallucinations Scale (LSHS), between 0 and 64 (higher scores indicate a greater likelihood of experiencing hallucinations) | Basline, before the stress procedure |