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To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.
Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality.
The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| With cardiovascular disease | Asthma patients with cardiovascular disease |
| |
| Without cardiovascular disease | Asthma patients without cardiovascular disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Asthma and cardiovascular disease | Other | To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical characteristics of patients with asthma | Spirometry with bronchodilator testing | 1 year |
| Associated cardiovascular disease type | Cardiac infarction, stroke or peripheral artery disease | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Eosinophil subtypes | Eosinophil subtypes of patients with asthma and cardiovascular disease | 1 year |
| Biomarkers of chronic inflammation | Transforming growth factor-β, interleukin-5, interleukin-13, interleukin-25 and interleukin-3 |
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Inclusion Criteria:
Exclusion Criteria:
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Asthmatic patients with and without cardiovascular disease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Esther Palones, MD | Contact | +34 93 556 56 01 | 5971 | epalones@santpau.cat |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35369308 | Result | Zhang B, Li ZF, An ZY, Zhang L, Wang JY, Hao MD, Jin YJ, Li D, Song AJ, Ren Q, Chen WB. Association Between Asthma and All-Cause Mortality and Cardiovascular Disease Morbidity and Mortality: A Meta-Analysis of Cohort Studies. Front Cardiovasc Med. 2022 Mar 17;9:861798. doi: 10.3389/fcvm.2022.861798. eCollection 2022. | |
| 28609456 | Result |
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Undecided
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| 1 year |
| Bronchial remodeling | Bronchial remodeling of patients with asthma and cardiovascular disease measured by analysis of images obtained by thoracic CT scanning | 1 year |
| Wang L, Gao S, Yu M, Sheng Z, Tan W. Association of asthma with coronary heart disease: A meta analysis of 11 trials. PLoS One. 2017 Jun 13;12(6):e0179335. doi: 10.1371/journal.pone.0179335. eCollection 2017. |
| 28377538 | Result | Xu M, Xu J, Yang X. Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis. Ann Saudi Med. 2017 Mar-Apr;37(2):99-105. doi: 10.5144/0256-4947.2017.99. |
| 28433577 | Result | Liu H, Fu Y, Wang K. Asthma and risk of coronary heart disease: A meta-analysis of cohort studies. Ann Allergy Asthma Immunol. 2017 Jun;118(6):689-695. doi: 10.1016/j.anai.2017.03.012. Epub 2017 Apr 19. |
| 10092690 | Result | Guite HF, Dundas R, Burney PG. Risk factors for death from asthma, chronic obstructive pulmonary disease, and cardiovascular disease after a hospital admission for asthma. Thorax. 1999 Apr;54(4):301-7. doi: 10.1136/thx.54.4.301. |
| 32369100 | Result | Banno A, Reddy AT, Lakshmi SP, Reddy RC. Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin Sci (Lond). 2020 May 15;134(9):1063-1079. doi: 10.1042/CS20191309. |
| 25448311 | Result | Lee HM, Liu MA, Barrett-Connor E, Wong ND. Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: the Rancho Bernardo study. Respir Med. 2014 Dec;108(12):1779-85. doi: 10.1016/j.rmed.2014.09.016. Epub 2014 Oct 6. |
| 6823813 | Result | Kannel WB, Hubert H, Lew EA. Vital capacity as a predictor of cardiovascular disease: the Framingham study. Am Heart J. 1983 Feb;105(2):311-5. doi: 10.1016/0002-8703(83)90532-x. No abstract available. |
| 14652302 | Result | Schroeder EB, Welch VL, Couper D, Nieto FJ, Liao D, Rosamond WD, Heiss G. Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2003 Dec 15;158(12):1171-81. doi: 10.1093/aje/kwg276. |
| 15947307 | Result | Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest. 2005 Jun;127(6):1952-9. doi: 10.1378/chest.127.6.1952. |
| 16551246 | Result | Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol. 2006;24:147-74. doi: 10.1146/annurev.immunol.24.021605.090720. |
| 32443594 | Result | Januskevicius A, Jurkeviciute E, Janulaityte I, Kalinauskaite-Zukauske V, Miliauskas S, Malakauskas K. Blood Eosinophils Subtypes and Their Survivability in Asthma Patients. Cells. 2020 May 18;9(5):1248. doi: 10.3390/cells9051248. |
| 27548519 | Result | Mesnil C, Raulier S, Paulissen G, Xiao X, Birrell MA, Pirottin D, Janss T, Starkl P, Ramery E, Henket M, Schleich FN, Radermecker M, Thielemans K, Gillet L, Thiry M, Belvisi MG, Louis R, Desmet C, Marichal T, Bureau F. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016 Sep 1;126(9):3279-95. doi: 10.1172/JCI85664. Epub 2016 Aug 22. |
| ID | Term |
|---|---|
| D001249 | Asthma |
| D002318 | Cardiovascular Diseases |
| D004802 | Eosinophilia |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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