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This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT.
A registry-based trial involves observing the effect of something without manipulating it.
The purpose of this study is to study the differences between CRT and SBRT. The investigator's are assessing radiation oncologists' decision-making during the evaluation of patients with spinal metastases by requesting radiation oncologists complete a questionnaire. Additionally, the investigator's will compare outcomes, including local progression, pain response and overall survival between SBRT and CRT. By collecting this information, the investigator's will develop an evidence-based algorithm that may be used to support medical decision-making for others with spinal metastases in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stereotactic Radiotherapy (SBRT) | Standard of care stereotactic radiotherapy. |
| |
| Conventional Radiotherapy (CRT) | Standard of care conventional radiotherapy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiotherapy | Radiation | Standard of care radiotherapy administered as per institutional guidelines. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Describe physician decision-making when making a recommendation for SBRT vs CRT in spine metastasis patients requiring radiation. | Physician's decision making will be assessed by a questionnaire containing 6 questions, including questions on variations of practice and the role of a number of factors that may influence a physician's recommendation for spine metastasis patients requiring radiation (SBRT vs CRT). | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Assess local progression free survival. | Based on available imaging, compare local progression free survival outcomes of patients treated with SBRT vs CRT. | 2 years |
| Measure pain response | Using a patient reported scale (0 (no pain) to 10 (worst pain imaginable)), compare pain outcomes of patients treated with SBRT vs CRT. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who have MRI- or CT-documented spinal metastases and are suitable for receiving radiation therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Shultz, MD | Contact | 416-946-4501 | 2121 | david.shultz@rmp.uhn.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Health Network | Recruiting | Toronto | Ontario | M5G 1X6 | Canada |
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| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| 2 years |
| Assess adverse events | Compare adverse events, collected through standard of care follow up, which occur for patients treated with SBRT vs CRT. | 2 years |
| Measure overall survival | Compare overall survival, collected through medical records, for patients treated with SBRT vs CRT. | 2 years |