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The goal of this clinical trial is to compare the effect of saturated fat intake from different source on cardiometabolic risk markers in healthy subjects. The main question it aims to answer are:
-Does intake of saturated fat in the form of high-fat yogurt have a different effect on cardiometabolic risk factors than intake of the same amount from butter? In this study, in two periods of 4 weeks, the effect of receiving saturated fat from high-fat yogurt compared to receiving the same amount of saturated fat from butter and low-fat yogurt on the plasma concentration of lipids, cholesterol, insulin, and some inflammatory factors will be studied in healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-fat yogurt | Experimental | Daily consumption of 1-2 servings (based on daily calorie requirement) of high-fat yogurt |
|
| Low-fat yogurt and butter | Active Comparator | Daily consumption of 1-2 servings of low-fat yogurt along with daily consumption of about 10 grams of animal butter |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| saturated fat intake | Other | Intake of saturated fat from yogurt and animal butter daily for 4-week period |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma lipid profile | Plasma concentrations of cholesterol, high-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, and triglyceride | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Glycemic measures | Fasting plasma concentrations of glucose and insulin | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory markers | Plasma concentrations of c-reactive protein and interleukin 6 | 4 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Nutrition Research Unit, National Nutrition and Food Technology Research Institute | Tehran | 19395-4741 | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38367032 | Derived | Ranjbar YR, Nasrollahzadeh J. Comparison of the impact of saturated fat from full-fat yogurt or low-fat yogurt and butter on cardiometabolic factors: a randomized cross-over trial. Eur J Nutr. 2024 Jun;63(4):1213-1224. doi: 10.1007/s00394-024-03352-8. Epub 2024 Feb 17. |
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