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Assessment of aging is central to health management. Compared to chronological age, biological age can better reflect the aging process and health status; however, an effective indicator of biological age in clinical practice is lacking. Human lens accumulates biological changes during aging and is amenable to a rapid and objective assessment. Therefore, the investigators will develop LensAge as an innovative indicator to reveal biological age based on deep learning using lens photographs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aging group | Participants with baseline information, medical history of diseases, and lens photographs |
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| Measure | Description | Time Frame |
|---|---|---|
| The difference between LensAge and chronological age | The age estimation models based on a convolutional neural network (CNN) using lens photographs will be used to generate LensAge. LensAge at the individual level will be calculated by averaging the results of all images corresponding to one individual. The difference between LensAge at the individual level and chronological age will be used to unveil an individual's aging process. A difference above 0 indicates an individual with a faster pace of aging than their peers of the same chronological age, while a difference below 0 indicates a slower pace of aging. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between the LensAge difference and age-related health parameters | Age-corrected LensAge differences will be used to investigate the odds ratios (ORs) with age-related health parameters. | Baseline |
| Mean absolute error (MAE) of the DL age estimation model. |
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Inclusion Criteria:
Exclusion Criteria:
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Participants aged 20 to 90 have anterior segment photographs, baseline information, and medical records.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Haotian Lin, M.D., Ph.D. | Contact | +86-020-87330274 | gddlht@aliyun.com |
| Name | Affiliation | Role |
|---|---|---|
| Haotian Lin, M.D., Ph.D. | Zhongshan Ophthalmic Center, Sun Yat-sen Univerisity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center, Sun Yat-sen Univerisity | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| ID | Term |
|---|---|
| D002386 | Cataract |
| ID | Term |
|---|---|
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
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Mean absolute error (MAE) in terms of both image level and individual level will be used to evaluate the performance of the DL age estimation model. |
| Baseline |
| Mean error (ME) of the DL age estimation model. | Mean error (ME) in terms of both image level and individual level will be used to evaluate the performance of the DL age estimation model. | Baseline |
| R-squared (R2) of the DL age estimation model. | R-squared (R2) in terms of both image level and individual level will be used to evaluate the performance of the DL age estimation model. | Baseline |