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Vascular malformations are birth defects that happen when different stages of angiogenesis shut down. 44 - 64% of all vascular malformations are venous malformations (VMs). Sclerotherapy is the first treatment line for VMs. It acts by getting rid of the vascular endothelial cells in the lesion. One of the most common and well researched sclerosing agents for VMs is polidocanol, which is a popular counterpart for concentrated ethanol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Direct Puncture Repair / Ethanol | Active Comparator |
| |
| Direct Puncture Repair / Polidocanol | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Direct Puncture Repair / Ethanol | Procedure | Ethanol is an organic compound that will be injected in the venous malformation as a sclerotherapy by Direct Puncture Repair |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heaviness questionnaire | Heaviness of the affected part may be unchanged, or decreased or disppeared, or relapsed | 6 months post operative |
| Disfigurement questionnaire | Disfigurementof the affected part may be unchanged, or decreased or disppeared, or relapsed | 6 months post operative |
| size of venous malformation | it assess the size of malformations after injection; which may be unchanged, or decreased or disppeared, or relapsed | 6 months post operative |
| Degree of satisfaction | It may be; Very satisfied, or satisfied, or not satisfied, or Dissatisfied. | 6 months post operative |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Walied Khereba | Zagazig | Egypt |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| D000077423 | Polidocanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D011092 | Polyethylene Glycols |
| D005026 | Ethylene Glycols |
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| Direct Puncture Repair / Polidocanol | Procedure | Polidocanol is a sclerosing agent that will be injected in the venous malformation by Direct Puncture Repair |
|
| D006018 |
| Glycols |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |