Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with high prevalence in patients suffering from chronic liver diseases [1]. NAFLD is characterized by the accumulation of > 5% of fat deposits in hepatocytes (hepatic steatosis) with no known other reasons for steatosis as excessive alcohol intake.The global prevalence of NAFLD differs depending on the population reaching 13% in Africa, 32% in the Middle East, and 30 % in the United States
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Placebo Comparator | 50 patients will receive the standard conventional therapy in addition to a placebo for 4 months. |
|
| Vit D Group | Active Comparator | 50 patients were given the standard conventional therapy plus cholecalciferol. Cholecalciferol was given as a high oral loading dose of 300,000 IU followed by a daily oral dose of 800 IU for 4 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cholecalciferol | Drug | Vit D is a fat-soluble vitamin, provided by sunlight and activated by kidneys and liver. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fasting blood glucose (FBG mg/dl) | 4 months | |
| Glycated hemoglobin (HbA1C%) | 4 months | |
| Fasting insulin (mU/L). | 4 months | |
| Alanine transaminase (ALT U/L) | 4 months | |
| Aspartate transaminase (AST U/L) | 4 months | |
| Albumin (g/dl) | 4 months | |
| Gamma-glutamyl transferase (GGT U/L) | 4 months | |
| Alkaline phosphatase (ALP U/L) | 4 months | |
| Lipid profile: Low-density lipoprotein (LDL-C mg/dl), High-density lipoprotein (HDL-C mg/dl) | 4 months | |
| Lipid profile: Triglycerides (TG mg/dl) | 4 months | |
| Lipid profile: Total cholesterol (TC mg/dl) | 4 months |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta Unuversity | Tanta | 31527 | Egypt |
Not provided
| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
double-blinded
| Placebo | Drug | matching placebo to Vit D |
|
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |